Welcome to the Huang Laboratory in the Departments of Microbiology and Immunology and of Pathology at the Geisel School of Medicine at Dartmouth, located at the Dartmouth Hitchcock Medical Center in Lebanon, New Hampshire.
T lymphocytes are a critical component of the adaptive immune system and provide specific protection against pathogens and cancer cells. Defects in T cell activation or migration lead to primary immunodeficiency diseases, characterized by increased susceptibility to viral and bacterial infections. However, T cell hyperactivity can result in autoimmune attack of one’s own tissue. The quality and magnitude of a T cell response are controlled by positive and negative cues from the microenvironment. We investigate how T cells appropriately and inappropriately translate activation and migration cues during a) thymocyte development, b) CD4 T cell differentiation, and c) tumor immune responses.