Huang Lab Publications

Resident memory CD8+ T cells in regional lymph nodes mediate immunity to metastatic melanoma.
Molodtsov AK, Khatwani N, Vella JL, Lewis KA, Zhao Y, Han J, Sullivan DE, Searles TG, Preiss NK, Shabaneh TB, Zhang P, Hawkes AR, Malik BT, Kolling FW 4th, Usherwood EJ, Wong SL, Phillips JD, Shirai K, Angeles CV, Yan S, Curiel TJ, Huang YH, Cheng C, Turk MJ
Immunity. 2021 Sep 14;54(9):2117-2132.e7. doi: 10.1016/j.immuni.2021.08.019. PMID: 34525340

IL-6 enhances CD4 cell motility by sustaining mitochondrial Ca2+ through the noncanonical STAT3 pathway.
Valenca-Pereira F, Fang Q, Marie IJ, Giddings EL, Fortner KA, Yang R, Villarino AV, Huang YH, Frank DA, Wen H, Levy DE, Rincon M
Proc Natl Acad Sci U S A. 2021 Sep 14;118(37) pii: e2103444118. doi: 10.1073/pnas.2103444118. PMID: 34507993

Dendritic cells maintain anti-tumor immunity by positioning CD8 skin-resident memory T cells.
Vella JL, Molodtsov A, Angeles CV, Branchini BR, Turk MJ, Huang YH
Life Sci Alliance. 2021 Oct;4(10) pii: e202101056. doi: 10.26508/lsa.202101056. Epub 2021 Aug 6. PMID: 34362825

Engineering a natural ligand-based CAR: directed evolution of the stress-receptor NKp30.
Butler SE, Brog RA, Chang CH, Sentman CL, Huang YH, Ackerman ME
Cancer Immunol Immunother. 2021 May 27; doi: 10.1007/s00262-021-02971-y. Epub 2021 May 27.
PMID: 34046711

Diverse Roles of Akt in T cells.
Abdullah L, Hills LB, Winter EB, Huang YH
Immunometabolism. 2021;3(1) pii: e210007. doi: 10.20900/immunometab20210007. Epub 2021 Jan 28. PMID: 33604081

Foxo1 Serine 209 Is a Critical Regulatory Site of CD8 T Cell Differentiation and Survival.
Hills LB, Abdullah L, Lust HE, Degefu H, Huang YH
J Immunol. 2021 Jan 1;206(1):89-100. doi: 10.4049/jimmunol.2000216. Epub 2020 Nov 23. PMID: 33229443

Control of B Cell Lymphoma by Gammaherpesvirus-Induced Memory CD8 T Cells.
Preiss NK, Kang T, Usherwood YK, Huang YH, Branchini BR, Usherwood EJ
J Immunol. 2020 Dec 15;205(12):3372-3382. doi: 10.4049/jimmunol.2000734. Epub 2020 Nov 13. PMID: 33188072

AMPK Activation by Metformin Promotes Survival of Dormant ER+ Breast Cancer Cells.
Hampsch RA, Wells JD, Traphagen NA, McCleery CF, Fields JL, Shee K, Dillon LM, Pooler DB, Lewis LD, Demidenko E, Huang YH, Marotti JD, Goen AE, Kinlaw WB, Miller TW
Clin Cancer Res. 2020 Jul 15;26(14):3707-3719. doi: 10.1158/1078-0432.CCR-20-0269. Epub 2020 Apr 22. PMID: 32321715

IL-17A-Induced PLET1 Expression Contributes to Tissue Repair and Colon Tumorigenesis.
Zepp JA, Zhao J, Liu C, Bulek K, Wu L, Chen X, Hao Y, Wang Z, Wang X, Ouyang W, Kalady MF, Carman J, Yang WP, Zhu J, Blackburn C, Huang YH, Hamilton TA, Su B, Li X
J Immunol. 2017 Dec 1;199(11):3849-3857. doi: 10.4049/jimmunol.1601540. Epub 2017 Oct 25. PMID: 29070673

Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis.
Li N, Xu W, Yuan Y, Ayithan N, Imai Y, Wu X, Miller H, Olson M, Feng Y, Huang YH, Jo Turk M, Hwang ST, Malarkannan S, Wang L. Sci Rep. 2017 May 3;7(1):1485. doi: 10.1038/s41598-017-01411-1. PMID: 28469254

Resident memory T cells in the skin mediate durable immunity to melanoma.
Malik BT, Byrne KT, Vella JL, Zhang P, Shabaneh TB, Steinberg SM, Molodtsov AK, Bowers JS, Angeles CV, Paulos CM, Huang YH, Turk MJ. Sci Immunol. 2017 Apr 14;2(10). pii: eaam6346. doi: 10.1126/sciimmunol.aam6346. PMID: 28738020

Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancer.
Hampsch RA, Shee K, Bates D, Lewis LD, Désiré L, Leblond B, Stefan K, Huang YH, Miller TW. Oncotarget. 2017 Mar 28;8(13):21806-21817. PMID: 28423521. PMCID: PMC5400625

Mst1 Kinase Regulates the Actin-Bundling Protein L-Plastin To Promote T Cell Migration.
Xu X, Wang X, Todd EM, Jaeger ER, Vella JL, Mooren OL, Feng Y, Hu J, Cooper JA, Morley SC, Huang YH. Journal of immunology (Baltimore, Md. : 1950). 2016; 197(5):1683-91. NIHMSID: NIHMS800157 PMID: 27465533 PMCID: PMC4992580

Non-canonical antagonism of PI3K by the kinase Itpkb delays thymocyte β-selection and renders it Notch-dependent.
Westernberg L, Conche C, Huang YH, Rigaud S, Deng Y, Siegemund S, Mukherjee S, Nosaka L, Das J, Sauer K. eLife. 2016; 5. PMID: 26880557 PMCID: PMC4764578

Melanoma Induces, and Adenosine Suppresses, CXCR3-Cognate Chemokine Production and T-cell Infiltration of Lungs Bearing Metastatic-like Disease.
Clancy-Thompson E, Perekslis TJ, Croteau W, Alexander MP, Chabanet TB, Turk MJ, Huang YH, Mullins DW. Cancer immunology research. 2015; 3(8):956-67. NIHMSID: NIHMS698371 PMID: 26048575 PMCID: PMC4527878

Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses.
Liu J, Yuan Y, Chen W, Putra J, Suriawinata AA, Schenk AD, Miller HE, Guleria I, Barth RJ, Huang YH, Wang L. Proceedings of the National Academy of Sciences of the United States of America. 2015; 112(21):6682-7. PMID: 25964334 PMCID: PMC4450438

Lipid and Protein Co-Regulation of PI3K Effectors Akt and Itk in Lymphocytes.
Wang X, Hills LB, Huang YH. Frontiers in immunology. 2015; 6:117. PMID: 25821452 PMCID: PMC4358224

Mst1 directs Myosin IIa partitioning of low and higher affinity integrins during T cell migration.
Xu X, Jaeger ER, Wang X, Lagler-Ferrez E, Batalov S, Mathis NL, Wiltshire T, Walker JR, Cooke MP, Sauer K, Huang YH. PloS one. 2014; 9(8):e105561. PMID: 25133611 PMCID: PMC4136924

Calmodulin and PI(3,4,5)P₃ cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production.
Wang X, Boyken SE, Hu J, Xu X, Rimer RP, Shea MA, Shaw AS, Andreotti AH, Huang YH. Science signaling. 2014; 7(337):ra74. NIHMSID: NIHMS648791 PMID: 25097034 PMCID: PMC4269470

The Wnt/planar cell polarity pathway component Vangl2 induces synapse formation through direct control of N-cadherin.
Nagaoka T, Ohashi R, Inutsuka A, Sakai S, Fujisawa N, Yokoyama M, Huang YH, Igarashi M, Kishi M. Cell reports. 2014; 6(5):916-27. PMID: 24582966

Rodent herpesvirus Peru encodes a secreted chemokine decoy receptor.
Lubman OY, Cella M, Wang X, Monte K, Lenschow DJ, Huang YH, Fremont DH. Journal of virology. 2014; 88(1):538-46. PMID: 24173234 PMCID: PMC3911705

Inositol tetrakisphosphate limits NK cell effector functions by controlling PI3K signaling.
Sauer K, Park E, Siegemund S, French AR, Wahle JA, Sternberg L, Rigaud S, Jonsson AH, Yokoyama WM, Huang YH. Blood. 2013; 121(2):286-97. PMID: 23175687 PMCID: PMC3544114

Lipid signaling in T-cell development and function.
Huang YH, Sauer K. Cold Spring Harbor perspectives in biology. 2010; 2(11):a002428. NIHMSID: NIHMS248502 PMID: 20943760 PMCID: PMC2964181

Kinase suppressor of Ras 1 is required for full ERK activation in thymocytes but not for thymocyte selection.
Filbert EL, Nguyen A, Markiewicz MA, Fowlkes BJ, Huang YH, Shaw AS. European journal of immunology. 2010; 40(11):3226-34. NIHMSID: NIHMS230989 PMID: 20865788 PMCID: PMC2976810

Immunology. CAR’ing for the skin.
Shaw AS, Huang Y. Science (New York, N.Y.). 2010; 329(5996):1154-5. PMID: 20813941

Phosphoinositide and inositol phosphate analysis in lymphocyte activation.
Sauer K, Huang YH, Lin H, Sandberg M, Mayr GW. Current protocols in immunology. 2009; Chapter 11:Unit11.1. NIHMSID: NIHMS161921 PMID: 19918943 PMCID: PMC4500525

Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling.
Fu G, Vallée S, Rybakin V, McGuire MV, Ampudia J, Brockmeyer C, Salek M, Fallen PR, Hoerter JA, Munshi A, Huang YH, Hu J, Fox HS, Sauer K, Acuto O, Gascoigne NR. Nature immunology. 2009; 10(8):848-56. NIHMSID: NIHMS122985 PMID: 19597499 PMCID: PMC2757056

New therapeutic targets in immune disorders: ItpkB, Orai1 and UNC93B.
Huang YH, Hoebe K, Sauer K. Expert opinion on therapeutic targets. 2008; 12(4):391-413. PMID: 18348677

Positive regulation of Itk PH domain function by soluble IP4.
Huang YH, Grasis JA, Miller AT, Xu R, Soonthornvacharin S, Andreotti AH, Tsoukas CD, Cooke MP, Sauer K. Science (New York, N.Y.). 2007; 316(5826):886-9. PMID: 17412921

Production of Ins(1,3,4,5)P4 mediated by the kinase Itpkb inhibits store-operated calcium channels and regulates B cell selection and activation.
Miller AT, Sandberg M, Huang YH, Young M, Sutton S, Sauer K, Cooke MP. Nature immunology. 2007; 8(5):514-21. PMID: 17417640

Integrating traditional and postgenomic approaches to investigate lymphocyte development and function.
Huang YH, Barouch-Bentov R, Herman A, Walker J, Sauer K. Advances in experimental medicine and biology. 2006; 584:245-76. PMID: 16802612

Dynamic repositioning of CD4 and CD8 genes during T cell development.
Delaire S, Huang YH, Chan SW, Robey EA. The Journal of experimental medicine. 2004; 200(11):1427-35. PMID: 15583015 PMCID: PMC2211942

Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch, and positive selection signals.
Huang YH, Li D, Winoto A, Robey EA. Proceedings of the National Academy of Sciences of the United States of America. 2004; 101(14):4936-41. PMID: 15044701 PMCID: PMC387352

Notch signaling in lymphocyte development.
Anderson AC, Robey EA, Huang YH. Current opinion in genetics & development. 2001; 11(5):554-60. PMID: 11532398