In a major milestone for Dartmouth and for the future of molecularly guided cancer surgery, Dartmouth has gained FDA approval for a study that may give surgeons a new “guiding light” during cancer surgeries.
The approval gives Dartmouth the go-ahead for the first study involving humans of a fluorescent agent for guiding tumor surgery. The agent, called ABY-029, binds to cancer cell receptors and highlights tumors during surgery. It’s a small, non-biologically produced molecule that is expected to provoke little, if any, immune response.
“Our approach will dramatically accelerate the paradigm shift towards molecularly guided surgical oncology,” says Keith Paulsen, the Robert A. Pritzker Professor of Biomedical Engineering and scientific director of Dartmouth’s Center for Surgical Innovation. “Dartmouth’s platform created a unique path for reducing the up-front costs of producing imaging agents for intraoperative use that allowed us to realize this new molecular probe for guiding surgery. And with FDA approval, we can now test how well it works.”
Read the full story at http://news.dartmouth.edu/news/2016/10/dartmouth-wins-fda-approval-aid-guide-cancer-surgery
Brian Pogue, Professor of Engineering and Director of MS and PhD Programs, has been selected by the American Institute for Medical and Biological Engineering (AIMBE) as a new member of its College of Fellows. AIMBE Fellows represent the top two percent of national medical and biological engineers, and are recognized for their scholarly work in the field. Brian, who joins Thayer Professor John Zhang and Professor Emeritus Bob Dean as an AIMBE Fellow, was recognized for his work in biomedical optics and imaging. Congratulations Brian!
Thayer School of Engineering 2014 graduate Rongxiao Zhang’s image was featured on the cover of the Optical Society of America’s Optics & Photonics News in September 2015. Optics in Medicine Laboratory Director Brian W. Pogue authored the accompanying cover story, “Optics in the Molecular Imaging Race.” Check it out at OSA September 2015.
Dartmouth’s Jacqueline Andreozzi was awarded the 1st place prize in the 2015 John R. Cameron Young Investigators’ Competition by the American Association of Physicists in Medicine (AAPM).
The John R. Cameron Young Investigators Symposium features an annual competition for new investigators in honor of University of Wisconsin Professor Emeritus Dr. John Cameron, a founding member of the AAPM. Of the many submissions from young investigators, reviewers selected the 10 highest scoring abstracts for presentation during a special symposium. The top three award winners were recognized during the AAPM Annual Meeting Awards and Honors Ceremony on Monday, July 13, 2015, in Anaheim CA, each receiving a plaque and a cash award.
Jacqueline’s abstract is entitled “Rapid Treatment Field Uniformity Optimization for Total Skin Electron Beam Therapy Using Cherenkov Imaging” and it can be found at: Jacqueline Andreozzi AAPM abstract
The Optics in Medicine Overlay GUI is a MATLAB-based graphical user interface which facilitates overlaying parametric maps on top of white-light images for:
- Displaying fluorescence-whitelight fused images for surgical guidance
- Exploring perceptual colormaps and plotting them on the 1931 CIE chromaticity diagram.
- Testing color blindness compatibility
- Determining best practices for colormap and transparency visualization
Questions, comments and bug reports can be made to Jonathan.T.Elliott@dartmouth.edu
(NEW) Download Overlay GUI v4.4.1-beta
Stephen C. Kanick, PhD and David W. Roberts, MD (DHMC Neurosurgery) are co-PIs on a 2015 SYNERGY Translational Pilot Grant entitled “Multiplexed Quantitative Assessment of Fluorescence Guided Neurosurgery.”
Neurosurgeons use fluorescent markers to provide visualization of important functional features of the brain. Some markers can be used to identify differences in tissue metabolic activity, and other tracers can identify leaky blood vessels that are associated with tumors. While most fluorescence guided surgery approaches rely on the eye of the surgeon to identify fluorescence light emitted by a single tracer, we are developing advanced optical approaches to independently estimate multiple fluorescence tracers. These approaches also provide measurements of the absolute value of the tracer concentration without distortions from blood absorption or tissue scattering within the surgical field. This SYNERGY grant focuses on the pilot clinical translation of a fiber optic approach to measure multiple fluorescent tracers during tumor resection surgeries.
Dartmouth SYNERGY works to speed the impact of discovery and translate new knowledge into practice and improved population health. By connecting to critical resources, funding opportunities, technologies, research training, and expertise, SYNERGY helps investigators advance research and efficiently translate discoveries into improved population health.
The SYNERGY Translational Pilot Program facilitates collaborative translational research studies across Dartmouth and affiliated health centers and communities. Pilot funding is intended to stimulate translational innovation, with a positive impact upon our overall clinical and translational research enterprise. The Translational Pilot Program systematically identifies, reviews, and selects novel multi- and interdisciplinary research concepts that have maximal potential for translation into patient care and population health. Dartmouth SYNERGY Clinical and Translational Science Institute is funded through the National Institutes of Health (NIH) Clinical and Translational Science Award (CTSA) program. The CTSA program is led by the NIH’s National Center for Advancing Translational Sciences (NCATS).