The paper was entitled, “Quantitative molecular imaging of intracellular signaling in an in ovo avatar model of pancreatic cancer for predicting personalized response to molecular therapies within one week of laparoscopic biopsy.” Dr. Samkoe presented the clinical and laboratory research and findings of the study she led with colleagues from the Illinois Institute for Technology and the Oregon Health and Science University.
In the study, human tumor lines were used to produce in ovo avatars and to develop and validate a rapid, in vivo assay that predicts therapy efficacy outcomes through changes in intracellular signaling proteins for individual patients. Dr. Samkoe and her research partners believe this model will be substantially faster and more cost effective than traditional patient-derived xenograft mouse models.
Brian Pogue, Professor of Engineering at the Thayer School of Engineering at Dartmouth, has been named Editor-in-Chief of the Journal of Biomedical Optics (JBO).
JBO is issued by SPIE (the international society for optics and photonics) and publishes peer-reviewed papers on the use of modern optical technology for improved healthcare and biomedical research.
Brian will begin his term in 2018 and aims to highlight advances at the intersection of emerging optical/photonic technologies and biomedical needs. Recognized as an expert in Optical Imaging, Brian is a fellow of both the Optical Society of America as well as the American Institute of Medical and Biological Engineering.
Pogue has been conference chair of the Molecular Guided Surgery: Molecules, Devices, and Applications conference at SPIE BiOS since 2015, and has been a JBO editorial board member since 2007.
AAPM’s “Best in Physics” presentations are the 15 studies that score highest in the abstract review process. Five studies in each of three categories – imaging, therapy and joint imaging-therapy – are then judged by scientific program directors to reflect the highest levels of scientific quality and innovation. Founded in 1958, AAPM seeks to identify and implement improvements in patient safety for the medical use of radiation in imaging and radiation therapy.
The best information on cancer tumor metabolism and immunology can be derived by analyzing tumors at a molecular level. While current imaging technology provides wonderful data on structural features (bones and organs), it does not yield detailed, high resolution images of the molecular features of a tumor because of their location deep beneath the skin
Following the invention at Dartmouth of a novel high-resolution, deep-tissue, imaging application, National Institute of Biomedical Imaging and Bioengineering (NIBIB) funding will be used by Principal Investigator Brian Pogueto further develop whole body scanning of concentrations in the sub-microMolar range. The new approach uses thin sheets of MegaVolt x-ray from a linear accelerator (LINAC), shaped by a multileaf collimator, to induce Cherenkov excitation of luminescence for scanned imaging (CELSI). Ultimately, a commercial prototype will be created.
At the end of April 2017, PhD student Ethan LaRochelle and OIM Lab Assistant Kayla Marra traveled to El Rosario, a rural village in the Yoro department of Honduras to take part in a cancer screening project organized by the Norris Cotton Cancer Center in partnership with ACTS Honduras.
Over 300 men ranging in ages 18-96 travelled from 38 surrounding villages to receive cancer screening and education.
In this study, researchers performed daylight photodynamic therapy (PDT) – a technique that the OIM group has researched pre-clinically in the lab – on any pre-cancerous or cancerous skin lesions identified.
Thayer’s researchers took spectral measurements of the sun and determined that it was feasible to deliver an adequate light dose.
The next step in this study is to recruit patients at La Liga Contra el Cancer in San Pedro Sula (an urban area that receives a broad patient population) by coordinating with Honduran dermatologists and oncologists.
Professor Elliott’s presentation is entitled, “Molecular Guided Surgery for Improved Brain Tumor Resection,” part of a session on Intraoperative Detection Devices and Probes. The session will cover identifying appropriate clinical/investigational applications for fluorescence molecular imaging, adopting emerging biomedical fluorescence imaging technologies to improve accuracy of surgical margins and improve patient outcomes. Professor Elliott is joined at this session by distinguished colleagues from the Washington University School of Medicine, Stanford University, and Emory University.
Funded by an NIH/NCI K99 “Pathway to Independence” grant, Professor Elliott’s research in the Center for Imaging Medicine at the Thayer School of Engineering focuses on using molecular targeted fluorescence and kinetic imaging to enhance contrast between tumor and normal tissue.