Henderson’s NCCC Prouty Pilot award for ABY-029

Congratulations  to Dr. Eric Henderson, Assistant Professor of Orthopaedic Surgery at the Geisel School and Program Director for DHMC’s Sarcoma & Connective Tissue Oncology program, for his recent $100k award from the Norris Cotton Cancer Center Developmental Funds, a Prouty Pilot Project.

The award will support a Clinical Research study using ABY-029  in a small number of subjects with Non-Metastatic Soft-Tissue Sarcoma.  Sarcomas are cancers of bone, muscle, and fat that require complete surgical removal for their cure.  In sarcoma surgery, the goal is to completely remove the tumor with a small margin of normal tissue surrounding it, while leaving in place vital structures.  For the last 30 years, surgeons have relied on radiologic imaging and visual/tactile clues to gauge tumor depth, an imperfect practice.    To provide surgeons with knowledge of the tumor margin thickness in real time would be an important advance.

ABY-029 is a novel fluorescent marker created through an NIH-funded Academic-Industrial Partnership championed by Thayer School Investigators Brian Pogue and Keith Paulsen.  Following FDA approval, the sarcoma study will be the second study to use ABY-029 in humans.  Thayer researchers are also working toward approval to use the drug in a third study involving subjects with head and neck cancers.



Elliott awarded NCI K99 grant for Molecularly Guided Surgery

Jonathan Elliott, PhD, was awarded a “Pathway to Independence” grant from the National Cancer Institute in August 2016.  Entitled “Molecularly Guided Surgery for Improved Resection of Glioblastoma Multiforme,” the grant project aims to accelerate Professor Elliott’s promising research career by building upon Dartmouth’s ongoing work in fluorescence-guided surgery (FGS) with ABY-029, the agent approved by FDA for a first-in-human clinical trial.  These two-year grants are given to outstanding postdoctoral researchers to help them advance to tenure-track or equivalent faculty positions.  Funds support Dr. Elliott’s mentored-training program with a core group of NIH-funded researchers at Dartmouth Hitchcock Medical Center (DHMC), including Dr. David Roberts, with Professors Keith Paulsen and Brian Pogue at the Thayer School of Engineering, and Dr. Jack Hoopes in the Geisel School of Medicine. Professor Elliott will conduct a pre-clinical research project to develop and evaluate a new approach to molecular-guided surgery – intraoperative receptor concentration imaging (iRCI). 


Pogue selected as AIMBE Fellow

Brian Pogue, Professor of Engineering and Director of MS and PhD Programs, has been selected by the American Institute for Medical and Biological Engineering (AIMBE) as a new member of its College of Fellows.  AIMBE Fellows represent the top two percent of national medical and biological engineers, and are recognized for their scholarly work in the field.  Brian, who joins Thayer Professor John Zhang and Professor Emeritus Bob Dean as an AIMBE Fellow, was recognized for his work in biomedical optics and imaging.  Congratulations Brian!

Nirfast Workshop at OSA

Prior to the 2016 Optical Society of America Conference in Miami, FL, a one-day Nirfast training was held. The training was organized by Scott Davis and Brian Pogue, Dartmouth College, USA and Hamid Dehghani, University of Birmingham, UK.  The workshop provided a hands-on tutorial for the modeling of diffuse light propagation in tissue, parameter recovery and data analysis.  Visit the Nirfast page for more information about this software.