Stephen Kanick has received a 5-year NIH Mentored Quantitative Research Career Development Award (K25) to support work with mentors Jack Hoopes, Brian Pogue, and Eunice Chen. The K25 awards provide support and a period of supervised study and research for professionals with quantitative (e.g., mathematics, statistics, economics, computer science, imaging science, informatics, physics, chemistry) and engineering backgrounds to integrate their expertise with NIH-relevant research.
Kanick received his Ph.D from the University of Pittsburgh, and spent 3 and a half years as a Post-doctoral researcher at the Erasmus Medical Center in The Netherlands before coming to the Thayer School in 2010 as a research scientist. He is now an Assistant Professor of Engineering Science at Thayer.
Surgery is the cornerstone of oncology treatment, and molecularly-targeted fluorescent imaging agents have the potential to guide surgical resection by highlighting the biological margins of the disease. However, development and testing of such molecular imaging agents has been lacking. Thayer School of Engineering and Geisel School of Medicine at Dartmouth together with LI-COR Biosciences and Affibody AB announce a new Academic/Industry Partnership to establish an efficient pipeline for development and translation of molecularly-targeted agents. The five-year project is funded by the National Cancer Institute.
This groundbreaking study will use a cost-effective, risk-diluted approach for rapid development and testing of molecularly-targeted imaging agents in phase 0 microdosing studies. The microdosing studies are designed to evaluate imaging of specific targets.
Jonathan Elliott, Ph.D. is a recent recipient of a Canadian Institutes of Health Research Fellowship award to work at Dartmouth on methods for imaging of surgical specimens for residual cancer. This competitive award from the Canadian government funds his work at Dartmouth, leveraging the medical imaging systems and physician researchers working on breast surgical imaging. His focus in this project involves breast lumpectomy tissue imaging ex vivo, and designing an optimal imaging system and approach for maximizing sensitivity to the micromorphologic contrast which can be present.
M.D./P.hD. candidate and Optics in Medicine Laboratory member Kelly Michaelsen was selected as a 2013 New Hampshire-Vermont Schweitzer Fellow. Founded in 1996, the Schweitzer fellowship is dedicated to developing healthcare professionals who are committed to addressing unmet health needs. Michaelsen’s Schweitzer project works to connect Dartmouth students and seniors through intergenerational programing at the Bugbee Senior Center in White River Junction, VT.
In the latest issue of Optics Letters, Dartmouth’s Optics in Medicine Laboratory published an article titled Čerenkov excited fluorescence tomography using external beam radiation. Conducted by graduate students Jennifer-Lynn Demers, Rongxiao Zhang, research scientist Scott Davis, lab director Brian Pogue, and Associate Professor of Medicine David Gladstone, the study examines the use of Čerenkov radiation in non-invasive cancer treatment. In this study, the lab examines a cancer treatment method that combines external beam radiation therapy (EBRT) with optical measurement of targeted fluorophore excited by Čerenkov radiation. In the study, optical measurements were taken from 13 locations on a tissue phantom to separate the fluorophore emissions from the Čerenkov continuum.
The research of Optics in Medicine Laboratory members Adam Glaser, Stephen Kanick, Rongxiao Zhang, and lab director Brian Pogue is featured in the latest volume of Biomedical Optics Express. Published by the Optics Society of America on April 17, 2013, A GAMOS plug-in for GEANT4 based Monte Carlo simulation of radiation-induced light transport in biological media describes a tissue optics plug-in that interfaces with the GENAT4/GAMOS Monte Carlo (MC) architecture. The paper presents the development of the program that extends enhanced capabilities for users to simulate optical photon transport through turbid media. In addition, this publication also provides examples of applications of the Čerenkov effect—a light pattern that occurs when a radiation beam enters water—within a medical context.
The GENAT4/GAMOS Monte Carlo (MC) plug-in is now available for free download. The Optics in Medicine Laboratory has also released a user’s manual for the software, example simulation files, and a MATLAB file of the program.