Molecular Imaging with Cherenkov Excited Light Sheets

DoD Breast Cancer Research Program Funding (PIs Brian Pogue & Lesley Jarvis)

Cherenkov light is stimulated by high energy radiation entering tissue, and emission of this light can be tailored to induce a light sheet within tissue.  This light sheet can be swept into the tissue, to allow high resolution molecular imaging of the signals, capturing luminescence or fluorescence from molecular probes.

Cherenkov excited light sheet luminescence imaging is a new methodology to provide the highest spatial resolution available for molecular signals at relevant tissue concentrations in the nM to uM range.  Detection of luminescence from lymph nodes or cancer tumors during radiotherapy is feasible, or diagnostic imaging at lower doses is also feasible.

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