Molecular Interactions & Imaging Core (MIIC)

Directors:
Henry Higgs, Ph.D.
Andreia Verissimo, Ph.D.

Contact:
Zdenek Svindrych, Ph.D.
Andreia Verissimo, Ph.D.
Angela Kull, M.S.
Pat Robison, Ph.D.

Location:
Vail Building, Room 309
Geisel School of Medicine, Hanover, NH
603.646.5182

INTERACTIONS AND IMAGING

The Molecular Interactions and Imaging Core (MIIC) enables research projects by offering support on numerous methodologies to characterize biomolecular interactions. In particular, we provide expertise on sample preparation (working with the MTC), data collection, and analysis for a range of instrumentation including surface plasmon resonance (label-free analysis of biomolecular interactions) and numerous measurements using absorbance, luminescence, and fluorescence (fluorescence anisotropy, alpha-screen, near-infrared fluorescence). The MIIC can facilitate access to additional instrumentation and various applications to characterize biological systems, including drug target identification and validation, such as isothermal calorimetry and nuclear magnetic resonance.

MICROSCOPY

Contact: 
Zdenek Svindrych, Ph.D.
Pat Robison, Ph.D.

We provide microscopy support to the bioMT community.  With a broad range of microscopes available at Dartmouth (either located in one of the imaging cores – Class of 1978 Life Sciences Center and Dartmouth-Hitchcock Medical Center, or in individual labs), we can cover many applications. The MIIC uses microscopy for both biochemical and cellular studies and assists investigators with designing and implementing methodologies to answer specific research questions.