High-throughput genomic, proteomic, metabolomic, and immune profiling technologies now provide a wealth of data that can be mined to interrogate basic biological process, changes in cellular or organismal populations, and the molecular bases of disease, at levels ranging from the whole organism to single cells. The generation and analysis of such data is now a pillar of research approaches and problems in the life sciences.
The Center for Quantitative Biology (CQB) will first nucleate and then grow this fusion of wet-bench “omics research” with bioinformatics at Dartmouth. Single-Cell Genomics (SCG) has become an essential tool to understand diseases involving complex biological systems, including cancer, neurodegeneration, and immune/autoimmune diseases. The overall goal of the SCG Core is to develop a centralized resource within the CQB to support individual project leaders and the Dartmouth community. The goal of this Core is to implement, maintain, and improve upon the technologies required to conduct SCG experiments in a rigorous and quality controlled manner. The SCG Core will work directly with COBRE leadership, project leaders, mentors, and investigators to design robust experiments and will implement stringent quality control and sample tracking methodologies.
Watch this presentation on the Single Cell Genomics Core
