Airway Cell Biology Core (CF LBC)

Co-directors:  George O’Toole, PhD, Professor of Microbiology and Immunology, and
Bruce Stanton, PhD, Professor of Microbiology and Immunology

Mixed microcolonies of P. aeruginosa (green) and S. aureus (red) on CF-derived airway epithelial in the Dartmouth Co-Culture Assay.

Description: The mission of the ACBC is to advance basic science, as well as translational and discovery studies relevant to interactions of microbes with host epithelial cells from the airway, provide expertise using a co-culture platform of bacterial biofilms on human epithelial cells  (including the Dartmouth Co-Culture Assay), and provide a range of airway cell lines, including primary human airway epithelial cells, organoids and 2D cultures from cystic fibrosis (CF) and non-CF donors, to support studies assessing host-microbe interactions relevant to the chronic infections associated with the CF airway.  The ACBC also assists in the development of new cell lines and other methodologies to advance the science of the RDP members and Pilot Project awardees.

Location: The ACBC is located in the Remsen Building on the Hanover campus of the Geisel School of Medicine.

Staff: Roxanna Barnaby, Ruina Bao

Contact: George O’Toole (georgeo@dartmouth.edu) or Bruce Stanton (bas@dartmouth.edu)