CF Bioinformatics & Biostatistics Core (P30)

Course faculty from 2019 Applied Bioinformatics course at the MDI Biological Laboratory.

Co-directors: Bruce Stanton, PhD, Professor of Microbiology and Immunology, and Todd MacKenzie, PhD, Professor of Biomedical Data Science

Description: The CF Bioinformatics and Biostatistics Core (CF-BBC) provides expert-level bioinformatics and biostatistical support and training to DartCF faculty and trainees, our partnering institutions, and to peer P30 CF Centers.  CF-BBC personnel will support:

  • Study design, including power analysis and choice of high throughput platform
  • Guidance on choice of statistical tools
  • Iterative, biology-driven, bioinformatics analysis of high throughput data including 16S metagenomics, proteomics, mRNA, lncRNA and miRNA
  • Drafting of figures and text for CF research manuscripts
  • Identification of opportunities for follow up experiments and manuscripts
  • Development of subject and sample annotation standards for CF sample data, beginning with 16S metagenomics samples
  • Development of a prototype CF data repository for CF metagenomic datasets (CFMDR)

Immune cell populations inferred from single cell gene expression data using T-distributed Stochastic Neighbor Embedding (t-SNE)

Training: The CF-BBC also provides training and educational opportunities to CF and biomedical data scientists,
including:

Bruce Stanton, Ph.D., chalk talk at 2019 Applied Bioinformatics Course, MDI Biological Laboratory.

  • Formal courses (Applied Bioinformatics and
    Microbiome Bioinformatics Workshop)
  • Weekly “R Club” seminars
  • Annual retreat to enhance the ability to perform collaborative research in CF involving large data sets.

Location: The CF-BBC office suite is located in 506 Remsen Building on the Hanover Campus of Dartmouth College.

Staff:  Thomas Hampton, PhD, Core Manager;
Katja Koeppen, PhD

Contact:  Thomas Hampton, PhD, Core Manager