Research in the Gilli Lab seeks to understand how “neuroinflammation” contributes to neurodegeneration. Our research is primarily focused on the molecular and immunological pathomechanisms that contribute to demyelination and neuroaxonal loss in Multiple Sclerosis. We utilize a broad range of approaches, ranging from molecular biology and immunology to gene expression profiling in the central nervous system and immune system. Our pre-clinical work often involves animal behavioral studies to define functional improvement after treatment, and we are involved in several collaborative translational clinical studies as well. The long-term goal of the research conducted in our laboratory is to provide new tools for the management of neurological diseases, which we believe will inform personalized therapeutic interventions. Ultimately this work will lead to a better understanding of the altered physiological pathways implicated in the pathogenesis of neurological conditions and will define targets for novel treatment approaches.
