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Software

Dowser

https://dowser.readthedocs.io

R package for B cell receptor phylogenetic analysis. Implements statistical tests for discrete trait analysis of B cell migration, differentiation, and isotype switching, as well as more recent tests developed to detect ongoing evolution in B cell lineages.

IgPhyML

https://igphyml.readthedocs.io

Phylogenetic analysis program designed for analyzing B cell receptor sequence data. Implements phylogenetic models capable of accounting for features of affinity maturation such as context dependent hotspot mutations and nonreversible sequence evolution.