The Nobel Assembly at Karolinksa Institute awarded the 2013 Nobel Prize in Physiology or Medicine to three scientists who solved the mystery of how the cell organizes its transport system for molecules in small packages called vesicles. The winners are James Rothman, Randy Schekman, and Thomas Sudhof.
According to the press release, “Randy Schekman discovered a set of genes that were required for vesicle traffic. James Rothman unravelled protein machinery that allows vesicles to fuse with their targets to permit transfer of cargo. Thomas Südhof revealed how signals instruct vesicles to release their cargo with precision.” Read the full press release at http://www.nobelprize.org/nobel_prizes/medicine/laureates/2013/press.html.
Read the key publications of these honored scientists:
- Novick P, Schekman R: Secretion and cell-surface growth are blocked in a temperature-sensitive mutant of Saccharomyces cerevisiae. Proc Natl Acad Sci USA 1979; 76:1858-1862.
- Balch WE, Dunphy WG, Braell WA, Rothman JE: Reconstitution of the transport of protein between successive compartments of the Golgi measured by the coupled incorporation of N-acetylglucosamine. Cell 1984; 39:405-416.
- Kaiser CA, Schekman R: Distinct sets of SEC genes govern transport vesicle formation and fusion early in the secretory pathway. Cell 1990; 61:723-733.
- Perin MS, Fried VA, Mignery GA, Jahn R, Südhof TC: Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C. Nature 1990; 345:260-263.
- Sollner T, Whiteheart W, Brunner M, Erdjument-Bromage H, Geromanos S, Tempst P, Rothman JE: SNAP receptor implicated in vesicle targeting and fusion. Nature 1993; 362:318-324.
- Hata Y, Slaughter CA, Südhof TC: Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin. Nature 1993; 366:347-351.
ISABEL is a differential diagnosis tool now on trial through October 26. It allows you to enter factors like age, gender, and clinical findings such as fever, hypertension, chills, and more. It then suggests diagnoses and links to additional information to help narrow the diagnosis. Try ISABEL.
More information about ISABEL.
Note that the entrance page has ISABEL on the left, and other products on the right. This is just the trial entrance: the front page is customizable. It does integrate with DynaMed, but it can also interfaces with other information resources such as UpToDate, Cochrane Library, and PubMed.
It should be self explanatory, but here is a quick look at how it works:
- Choose an age group and type in clinical features in the box provided. Use other fields as needed. Click “get checklist.”
- A list of possible diagnoses will be shown on the right. Clicking on one takes you into DynaMed’s “Making the Diagnosis” section for that disease.
- You can also use it to diagnose from symptoms caused by drug reactions or bioterrorism
- In the trial version, when you are looking at DynaMed’s diagnosis section you will see links to other resources at the left. Not all of these will work. If we purchased this product the list would be customized with resources available at Dartmouth.
Please try ISABEL and then let us know what you think by sending comments to Peggy Sleeth, Associate Director/Information Resources.
Photographs by Clara Gimenez
This selection of photographs reflects my interest in the texture and color of landscapes.
My method is very simple: I take my camera everywhere and wait for the opportunity to arise. Sometimes the opportunity is obvious, such as a magnificent sunset over the bay. Other times, the call is more subtle, like the print of wind-exposed sea grass on the sand.
I continue the experimentation with texture during the printing process, choosing between traditional photo paper, watercolor paper, or canvas to emphasize different aspects of the image.
For more information, contact me at firstname.lastname@example.org
Natural Standard, a database assessing herbal medicine, supplements, and other complementary and alternative therapies, is now available as a trial through September 20, 2013. Connect to http://www.naturalstandard.com.
Natural Standard describes itself as founded by healthcare providers and researchers to provide high-quality, evidence-based information about complementary and alternative medicine including dietary supplements and integrative therapies. Grades reflect the level of available scientific data for or against the use of each therapy for a specific medical condition. It is impartial; not supported by any interest group, professional organization or product manufacturer.
The evidence grading system is explained at http://www.naturalstandard.com/grading.asp.
Other sources of information about alternative therapies include free sites such as Medline Plus, HerbMed.org, the National Center for Complementary and Alternative Medicine, and the Office of Dietary Supplements, as well as comprehensive drug information resources from the Biomedical Libraries such as UpToDate, Clinical Pharmacology Online, DynaMed, and Micromedex.
Please provide feedback on Natural Standard to Peggy Sleeth, Associate Director for Information Resources.
Monday, May 27, 2013 Memorial Day
Matthews-Fuller Health Sciences Library:
Dana Biomedical Library @37 Dewey Field Road:
General Public – CLOSED
Dartmouth IDs – 7:30am-Midnight
Medical & Grad Students – 24 Hours
No Joke! On April 15th the Dana Biomedical Library will open in its new location at 37 Dewey Field Road. Photos from March 29th show the place is starting to shape up.
The Reading Room with its central table. All seating spaces will have easily accessible power outlets. The south end of the room has a generous window seat and the north wall will have 4 public computer stations.
This is the hallway to the staff offices. The shelves on the left will hold a small collection of topical books.
Room 339 is a 12 seat classroom. It will have movable tables and a large flat screen display. There are two additional classrooms in the library with 10 seats and 18 seats respectively.
This room and another just like it will have 9 individual study carrels. The glass wall will have a semi-transparent film applied. This should be a nice place to get in some serious study time.
For more detailed information, a floor plan, and a location map please visit this page.
The Biomedical Libraries are pleased to announce that Chris Fuller has joined our staff as our new Information Access Assistant. He moved here from Portland, Oregon to work with us, and to be closer to his family in New York state. He started on Wednesday, February 27.
Chris brings a rich background of library-related experience to this position. Chris has a BA in History and Communication from Rutgers University, and has just completed an MLIS from San Jose State University. He has worked at Kaiser Permanente as a Digital Projects Intern helping to create an institutional repository, and at the City of Portland Archives. He has also worked with copyright issues while an associate contracts manager at Simon & Schuster.
Last week construction started on the temporary home for Dana Biomedical Library at 37 Dewey Field Road. The 3rd floor of 37 Dewey was gutted and walls are now going up for offices, classrooms, study space and services.
Peggy Sleeth and Susan Jorgensen in the north end of what will be the open study space with tables, chairs and couches. This end also has 2 small class/meeting rooms. The other end has an 18 seat classroom.
Susan Jorgensen looking at the plans for the Public Services desk and staff offices with the project supervisor. Over the next 2 months this raw space will be transformed into bright, colorful and vibrant space for studying, class meetings, checking out materials and getting help with library resources.
The staff is scheduled to move to the new space in mid April and a few weeks later the collections will be moved out of Dana to an offsite facility. A small collection of reserves and reference books will be held in 37 Dewey, and a courier system is being established to fetch materials from the library storage facility.
This new space, which will be called Dana Biomedical Library at 37 Dewey Field Road, will be our home until the North Campus Academic Center is constructed on the current Gilman-Dana site. It is currently being planned for a 2016 opening.
We will be posting progress reports and updates as things progress.
Yes! The Dana Biomedical Library will be moving! Twice!
Our first move will be to 37 Dewey Field Road. This will be our temporary home in order to allow for the construction of the new North Campus Academic Center. Our interim Dana Library will provide library services and student study space in a warm and cheerful environment. And, we are exploring the possibility of having it available to students 24×7!
This first move will not occur before April 1, 2013. There will be no disruption of services at the current Dana Library during first term.
Our second move is now projected for the beginning of 2016, when the new North Campus Academic Center is scheduled to open.
During the interim period all of Dana’s print journal volumes and most of its books will be housed offsite; reserve material and a few other books will move with us to 37 Dewey Field. The material housed offsite will be quickly delivered to campus libraries upon request.
If you have questions about the moves, please contact us. We’ll post more details here in the future.
Click on the image below for a larger view of the floor plan for the interim Dana Library:
(Click on image for a larger view)