Christopher C. Pennil

Research Summary

Transcriptional Regulation of CFTR Inhibitory Factor (Cif) by CifR. Christopher Penn graduated from North Dakota State University with a M.S. degree in Microbiology in 2009. For the next 2.5 years he worked as a research scientist/technician for Dr. Elizabeth Swisher at the University of Washington and Fred Hutchinson Cancer Research Center, where his work focused primarily on the molecular genetics of ovarian cancer. In July of 2012 he moved to Hanover to work at Dartmouth in the lab of Dean Madden as a lab manager/technician. His research now focuses on a TetR family repressor protein, CifR, which negatively regulates the expression of Cif, a protein which decreases membrane expression of the cystic fibrosis transmembrane conductance regulator (CFTR).

Publications

H. M. Baden, T. Särkinen, D. A. Conde, A. C. Matthews, H. Vandrot, S. Chicas, C. Pennil, W. D. R. Bayly, R. Chance, S. G. M. Bridgewater and D. J. Harris. A botanical inventory of forest on karstic limestone and metamorphic substrate in the Chiquibul Forest, Belize, with focus on woody taxa. Edinburgh Journal of Botany, 1-43. Online publication date: 10-Nov-2015.

Pennington KP, Walsh T, Harrell MI, Lee MK, Pennil CC, Rendi MH, Thornton A, Norquist BM, Casadei S, Nord AS, Agnew KJ, Pritchard CC, Scroggins S, Garcia RL, King MC, Swisher EM. (2014) Germline and somatic mutations in homologous recombination genes predict platinum response and survival in ovarian, fallopian tube, and peritoneal carcinomas. Clin Cancer Res. 20(3): 764-75.

Norquist BM, Pennington KP, Agnew KJ, Harrell MI, Pennil CC, Lee MK, Casadei S, Thornton AM, Garcia RL, Walsh T, Swisher EM. (2013) Characteristics of women with ovarian carcinoma who have BRCA1 and BRCA2 mutations not identified by clinical testing. Gynecol Oncol.. 128(3): 483-7.

Pennington KP, Wickramanayake A, Norquist BM, Pennil CC, Garcia RL, Agnew KJ, Taniguchi T, Welcsh P, Swisher EM. (2013) 53BP1 Expression In Sporadic And Inherited Ovarian Carcinoma: Relationship To Genetic Status And Clinical Outcomes. Clin Cancer Res. 128(3): 493-9.

Pennington KP, Walsh T, Lee M, Pennil C, Novetsky AP, Agnew KJ, Thornton A, Garcia R, Mutch D, King MC, Goodfellow P, Swisher EM. (2013) BRCA1, TP53, and CHEK2 germline mutations in uterine serous carcinoma. Cancer.. 119(2): 332-8.

Wickramanyake A, Bernier G, Pennil C, Casadei S, Agnew K, Stray S, Mandell J, Garcia R, Walsh T, King MC, Swisher E. (2012) Loss of function germline mutations in RAD51D in women with ovarian carcinoma. Gynecol Oncol. 127(3): 552-5.

Press JZ, Reyes M, Pitteri SJ, Pennil C, Garcia R, Goff BA, Hanash SM, Swisher EM. (2012) Microparticles From Ovarian Carcinomas Are Shed Into Ascites and Promote Cell Migration. Int J Gynecol Cancer.. 22(4): 546-52.

Walsh T, Casadei S, Lee M, Pennil C, Nord A, Thornton A, Roeb W, Agnew K, Stray S, Wickramanayake A, Norquist B, Garcia R, King MC, Swisher E. (2011) Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing. Proc. Natl. Acad. Sci. USA.. 108(44): 18032-7.

Norquist B, Wurz KA, Pennil CC, Garcia R, Gross J, Sakai W, Karlan BY, Taniguchi T, Swisher EM. (2011) Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas. Journal of Clinical Oncology. 29(22): 3008-15.

Press JZ, Wurz K, Norquist B, Lee MK, Pennil C, Garcia R, Welcsh P, Goff BA, and Swisher EM. (2010) Identification of a preneoplastic gene expression profile in tubal epithelium of BRCA1 mutation carriers. Neoplasia.. 12: 993-1002.

Walsh T, Lee MK, Casadei S, Thornton AM, Stray SM, Pennil C, Nord AS, Mandell JB, Swisher EM, and King MC. (2010) Detection of inherited mutations for breast and ovarian cancer using genomic capture and massively parallel sequencing. Proc. Natl. Acad. Sci. USA. 107: 12629-33.