Exterior of Engineering and Computer Science Center (ECSC) buildings

Publications

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At Dartmouth:

(# denotes equal contribution, * denotes corresponding authors)

25. Caspase-3-Responsive, Fluorogenic Bivalent Bottlebrush Polymers

Zafar, H.; Liu, B.; Nguyen, H. V.-T.; Johnson, J. A.* ACS Macro Lett. 2024, 13, 571–576.

Abstract figure presenting enzyme accessibility towards bottlebrush polymers

24. An organometallic swap strategy for bottlebrush polymer–protein conjugate synthesis

Liu, B.; Rodriguez, J.; Kilgallon, L. J.; Wang, W.; Wang, Y.; Wang, A.; Dai, Y.; Nguyen, H. V.-T.; Pentelute, B. L.; Johnson, J. A.* Chem. Commun. 2024, 60, 4238–4241.

Abstract figure presenting organometallic swap strategy

Prior to Dartmouth:

(# denotes equal contribution, * denotes corresponding authors)

  1. Engineering Kinetics Of TLR7/8 Agonist Release From Bottlebrush Prodrugs Enables Tumor-Focused Immune Stimulation
    Bhagchandani, S.; Vohidov, F.;# Milling, L.;# Tong, E. Y.;# Brown, C. M.; Liu, B.; Fessenden, T.; Nguyen, H. V.-T.; Kiel, G. R.; Won, L.; Langer, R. S.; Spranger, S.; Shalek, A. K.; Irvine, D. J.;* Johnson, J. A.* Sci. Adv. 2023, 9, DOI: 10.1126/sciadv.adg2239.
  2. A Molecular Bottlebrush Prodrugs As Mono And Triplex Combination Therapies For Multiple Myeloma
    Detappe, A.;# Nguyen, H. V.-T.;# Jiang, Y.; Agius, M.; Wang, W.; Mathieu, C.; Su, N. K.; Kristufek, S. L.; Lundberg, D.; Bhagchandani, S.; Ghobrial, I. M.;* Ghoroghchian, P. P.;* Johnson, J. A.* Nat. Nanotechnol. 2023, 18, 184–192.
  3. Bottlebrush Polymers With Discrete Sidechains Display Stereochemistry- And Conformation-Dependent Biological Properties
    Nguyen, H. V.-T.;# Jiang, Y.;# Mohapatra, S.; Wang, W.; Barnes, J. C.; Oldenhuis, N. J.; Chen, K. K.; Axelrod, S.; Huang, Z.; Chen, Q.; Golder, M. R.; Young, K.; Suvlu, D.; Shen, Y.; Willard, A. P.; Hore, M. J. A.; Gomez-Bombarelli, R.;* Johnson, J. A.* Nat. Chem. 2022, 14, 85–93.
  4. Discrete, Chiral Polymer-Insulin Conjugates
    Wang, W.; Jiang, Y.; Huang, Z.; Nguyen, H. V.-T.; Liu, B.; Hartweg, M.; Shirakura, M.; Qin, K. P.; Johnson, J. A.* J. Am. Chem. Soc. 2022, 144, 23332–23339.
  5. Glycomacromolecules Of Defined Valency, Absolute Configuration, And Topology Distinguish Between Human Lectins
    Hartweg, M.;# Jiang, Y.;# Yilmaz, G.; Jarvis, C. M.; Nguyen, H. V.-T.; Primo, G. A.; Monaco, A.; Beyer, V. P.; Chen, K.; Mohapatra, S.; Axelrod, S.; Gomez-Bombarelli, R.; Kiessling, L. L.;* Becer, C. R.;* Johnson, J. A.* JACS Au 2021, 1, 1621–1630.
  6. Design Of BET Inhibitor Bottlebrush Prodrugs With Superior Efficacy And Devoid Of Systemic Toxicities
    Vohidov, F.;# Andersen, J. N.;# Economides, K. D.; Shipitsin, M. V.; Burenkova, O.; Ackley, J. C.; Vangamudi, B.; Nguyen, H. V.-T.; Gallagher, N. M.; Shieh, P.; Golder, M. R.; Liu, J.; Dahlberg, W. K.; Ehrlich, D. J.; Kim, J.; Kristufek, S. L.; Huh, S. J.; Neenan, A. M.; Baddour, J.; Paramasivan, S.; de Stanchina, E.; Gaurab, K.; Turnquist, D. J.; Saucier-Sawyer, J. K.; Kopesky, P. W.; Brady, S. W.; Jessel, M. J.; Reiter, L. A.; Chickering, D. E.; Johnson, J. A.;* Blume-Jensen, P.* J. Am. Chem. Soc. 2021, 143, 4714–4724.
  7. Pro-Organic Radical Contrast Agents (“Pro-ORCAs”) For Real-Time MRI Of Pro-Drug Activation In Biological Systems
    Nguyen, H. V.-T.;# Detappe, A.;# Harvey, P.; Gallagher, N. M.; Mathieu, C.; Agius, M. P.; Zavidij, O.; Wang, W.; Jiang, Y.; Rajca, A.; Jasanoff, A.; Ghobrial, I. M.; Ghoroghchian, P. P.;* Johnson, J. A.* Polym. Chem. 2020, 11, 4768–4779.
  8. ABC Triblock Bottlebrush Copolymer-Based Injectable Hydrogels: Design, Synthesis, And Application To Expanding The Therapeutic Index Of Cancer Immunochemotherapy
    Vohidov, F.;# Milling, L. E.;# Chen, Q.; Zhang, W.; Bhagchandani, S.; Nguyen, H. V.-T.; Irvine, D. J.;* Johnson, J. A.* Chem. Sci. 2020, 11, 5974–5986.
  9. Polyoxazoline-Based Bottlebrush and Brush-Arm Star Polymers via ROMP: Syntheses and Applications as Organic Radical Contrast Agents
    Gil Alvaradejo, G.;# Nguyen, H. V.-T.;# Harvey, P.; Gallagher, N. M.; Le, D.; Ottaviani, M. F.; Jasanoff, A.; Delaittre, G.;* Johnson, J. A.* ACS Macro Lett. 2019, 8, 473–478.
  10. Tailored Silyl Ether Monomers Enable Backbone-Degradable Polynorbornene-Based Linear, Bottlebrush, And Star Copolymers Through ROMP
    Shieh, P.; Nguyen, H. V.-T.; Johnson, J. A.* Nat. Chem. 2019, 11, 1124–1132.
  11. Modular Polymer Antigens To Optimize Immunity
    Bennett, N. R.;# Jarvis, C. M.;# Murshid Alam, M.; Zwick, D. B.; Olson, J. M.; Nguyen, H. V.-T.; Johnson, J. A.; Cook, M. E.; Kiessling, L. L.* Biomacromolecules 2019, 20, 4370–4379.
  12. Antibody-Targeting Of Ultra-Small Nanoparticles Enhances Imaging Sensitivity And Enables Longitudinal Tracking Of Multiple Myeloma
    Detappe, A.; Reidy, M.; Yu, Y.; Mathieu, C.; Nguyen, H. V.-T.; Coroller, T. P.; Lam, F.; Jarolim, P.; Harvey, P.; Protti, A.; Nguyen, Q.-D.; Johnson, J. A.; Cremilleux, Y.; Tillement, O.; Ghobrial, I. M.;* Ghoroghchian, P. P.* Nanoscale 2019, 11, 20485–20496.
  13. Robust Gold Nanorods Stabilized By Bidentate N-Heterocyclic Carbene-Thiolate Ligands
    MacLeod, M.; Goodman, A.; Ye, H.-Z.; Nguyen, H. V.-T.; Van Voorhis, Y.; Johnson, J. A.* Nat. Chem. 2019, 11, 57–63.
  14. Brush-First And ROMP-Out With Functional (Macro)Monomers: Method Development, Structural Investigations, And Applications Of An Expanded Brush-Arm Star Polymer Platform
    Golder, M. R.; Nguyen, H. V.-T.; Oldenhuis, N. J.; Grundler, J.; Park, E. J.; Johnson, J. A.* Macromolecules 2018, 51, 9861–9870.
  15. Triply Loaded Nitroxide Brush-Arm Star Polymers Enable Metal-Free Millimetric Tumor Detection By Magnetic Resonance Imaging
    Nguyen, H. V.-T.;# Detappe, A.;# Gallagher, N. M.; Zhang, H.; Harvey, P.; Yan, C.; Mathieu, C.; Golder, M. R.; Jiang, Y.; Ottaviani, M. F.; Jasanoff, A.; Rajca, A.; Ghobrial, I. M.; Ghoroghchian, P. P.;* Johnson, J. A.* ACS Nano 2018, 12, 11343–11354.
  16. Reduction Of Liver Fibrosis By Rationally Designed Macromolecular Telmisartan Prodrugs
    Golder, M. R.;# Liu, J.;# Andersen, J. N.; Shipitsin, M. V.; Vohidov, F.; Nguyen, H. V.-T.; Ehrlich, D. C.; Huh, S. J.; Vangamudi, B.; Economides, K. D.; Neenan, A. M.; Ackley, J. C.; Baddour, J.; Paramasivan, S.; Brady, S. W.; Held, E. J.; Reiter, L. A.; Saucier-Sawyer, J. K.; Kopesky, P. W.; Chickering, D. E.; Blume-Jensen, P.;* Johnson, J. A.* Nat. Biomed. Eng. 2018, 2, 822–830.
  17. Main-Chain-Zwitterionic Supramolecular Polymers Derived From N–Heterocyclic Carbene Carbodiimide (NHC–CDI) Adducts
    Gallagher, N. M.; Zhukhovitskiy, A. V.; Nguyen, H. V.-T.; Johnson, J. A.* Macromolecules 2018, 51, 3006–3016.
  18. Scalable Synthesis Of Multivalent Macromonomers For ROMP
    Nguyen, H. V.-T.; Gallagher, N. M.; Vohidov, F.; Jiang, Y.; Kawamoto, K.; Zhang, H.; Park, J. V.; Huang, Z.; Ottaviani, M. F.; Rajca, A.; Johnson, J. A.* ACS Macro Lett. 2018, 7, 472–476.
  19. Stereochemical Sequence Dictates Unimolecular Diblock Copolymer Assembly
    Golder, M. R.;# Jiang, Y.;# Teichen, P. E.; Nguyen, H. V.-T.; Wang, W.; Milos, N.; Freedman, S. A.; Willard, A. P.; Johnson, J. A.* J. Am. Chem. Soc. 2018, 140, 1596–1599.
  20. Mikto-Brush-Arm Star Polymers Via Cross-Linking Of Dissimilar Bottlebrushes: Synthesis And Solution Morphologies
    Shibuya, Y.; Nguyen, H. V.-T.; Johnson, J. A.* ACS Macro Lett. 2017, 6, 963–968.
  21. Nitroxide-Based Macromolecular Contrast Agents With Unprecedented Transverse Relaxivity And Stability For Magnetic Resonance Imaging Of Tumors
    Nguyen, H. V.-T.; Chen, Q.; Paletta, J. T.; Harvey, P.; Jiang, Y.; Zhang, H.; Boska, M. D.; Ottaviani, M. F.; Jasanoff, A.; Rajca, A.; Johnson, J. A.* ACS Cent. Sci. 2017, 3, 800–811.
  22. Using An RNAi Signature Assay To Guide The Design Of Three-Drug-Conjugated Nanoparticles With Validated Mechanisms, In Vivo Efficacy, And Low Toxicity
    Barnes, J. C.;# Bruno, P. M.;# Nguyen, H. V.-T.; Liao, L.; Liu, J.; Hemann, M. T.; Johnson, J. A.* J. Am. Chem. Soc. 2016, 138, 12494–12501.
  23. Iterative Exponential Growth Synthesis And Assembly Of Uniform Diblock Copolymers
    Jiang, Y.; Golder, M. R.; Nguyen, H. V.-T.; Wang, Y.; Zhong, M.; Barnes, J. C.; Ehrlich, D. J. C.; Johnson, J. A.* J. Am. Chem. Soc. 2016, 138, 9369–9372.