Rational Combination Therapy
We develop modular multivalent hydrogel platforms for drug delivery that enable the incorporation of several APIs with pre-programed ratios and release kinetics. We envision the generation of a library of API (e.g., potency) and linker (e.g., kinetics) that can operate in a LEGO-like ‘plug-and-play’ manner depending on the indication of interest.
Cancer Vaccine Potentiation
We explore the possibility of using ‘manufactured’ tumors as training mechanisms for the immune system. We utilize macroporous cryogels that are decorated with relevant components to enable systematic interrogations of the resulting immune response.
Protein Corona-Driven Nanomaterial Engineering
We develop a methodology for characterization of the protein corona via leveraging implanted hydrogels’ physical, which in turn enables facile extraction and characterization. We aim to establish a systematic understanding of the protein corona and thus, enabling rational nanomaterial designs that exploit these processes.