Dartmouth presents at SPIE Photonics West

In January 2017, researchers from the Thayer School of Engineering made more than 20 technical presentations at workshops during Photonics West, the “world’s largest photonics technologies event.” The conference is hosted by SPIE, the international society for optics and photonics, and is held each year in San Francisco. It draws about 20,000 attendees to 4,800 workshops in three conference tracks: Biomedical Optics and Biophotonics, Laser Sources and Lasers for Manufacturing, and Optoelectronic Materials and Devices.  Here’s the rundown:

  • Jaime Bravo – “In vivo optical properties of human brain tissue.”
  • Mackenzie Carlson – “Structured light scatteroscopy through a rigid endoscope provides unique real-time contrast based on tissue ultrastructure.”  Mackenzie and Bo McClatchy – “High spatial frequency RGB modulated imaging in comparison to cross-polarized imaging.”
  • Scott Davis – “Diffuse optical tomography for in vivo 3D vascular imaging of a murine bone graft model.”
  • Ana Luiza Ribeiro de Souza – “Comparison of doses delivered in daylight versus regular light delivery in ALA-PDT in the treatment of skin cancer.”
  • Eric Henderson, MD, of DHMC, presented his invited paper, “Novel applications of near-infrared fluorescence imaging in
    orthopedic surgery.”
  • Shudong Jiang and Yan Zhao – “Breast cancer detection using non-contrast T2-weighted-MRI imaging guided near infrared spectroscopy tomography” and “A portable, 12-wavelength parallel near-infrared spectral tomography (NIRST) system for efficient characterization of breast cancer during neoadjuvant chemotherapy.”
  • Ethan Larochelle – “In vivo wide-field multispectral dosimeter for use in ALA-PpIX based photodynamic therapy.”
  • Bo McClatchy – “Sub-diffusive spatial frequency domain imaging provides widefield visualization and quantification of light scattering as an endogenous biomarker for morphological change in tissue.”  Bo and Chad Kanick – “Label-free hyperspectral dark-field microscopy for quantitative scattering imaging of tissue-mimicking phantoms” and “Combined multispectral spatial frequency domain imaging and computed tomography system for intraoperative breast tumor margin assessment.”
  • Mike Nieskoski – “Quantification of localized total tissue pressure and extracellular matrix components as related to vascular patency and verteporfin uptake within pancreatic cancer.”
  • Brian Pogue chaired a three day conference, Molecular-Guided Surgery, for the third year with Sylvain Gioux, Universite de Strasbourg (France).  The conference wrapped up with a panel discussion that Brian moderated, regarding new devices for molecularly-guided surgery.  Brian also made two technical presentations on Cherenkov-excited luminescence and Cherenkov-excited imaging.
  • Keith Paulsen presented an invited paper entitled, “Technological advances on fluorescence-guided neurosurgery.”
  • Kim Samkoe – “Quantitative imaging of intracellular signaling for personalized pancreatic cancer therapy in an in ovo avatar” and “Evaluation of semi-automated method for coregistering fresh tissue fluorescence images with histopathology slides for preclinical evaluation of molecular guided surgery agents.”
  • Thayer researchers presented these posters:
    • Jason Gunn – “Pre-clinical development and safety testing of GMP produced ABY-029,
      fluorescent anti-EGFR affibody, for use in surgical resection.”
    • Kayla Marra – “Pre-clinical evaluation of fluorescent ABY-029 in 3 mouse sarcoma models, to assess enhanced contrast in fluorescence guided surgery relative to fluorescent perfusion contrast.”
    • “Review of fluorescence guided surgery systems: identification of key performance capabilities beyond ICG imaging.”
    • “Dexamethasone enhances 5-ALA/PpIX contrast but degrades ABY-029 contrast at glioma margins during fluorescence guided resection.”


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