McClatchy wins Strohbehn Memorial Prize

We congratulate Optics in Medicine group member and Thayer School of Engineering graduate David McClatchy III PhD on winning the John W. Strohbehn PhD Memorial Prize at Thayer’s 2018 Investiture Ceremony.  David (“Bo”) helped launch a major research program in imaging radiotherapy that now involves approximately 20 people.  Great work, Bo!

AAPM Spring Clinical National Young Investigator Symposium

Thayer School and Optics in Medicine group PhD student Irwin Tendler was selected at the AAPM Spring Clinical meeting as the 2nd place winner of the  National Young Investigator Symposium.

The meeting was held in Las Vegas and aims to help medical physicists integrate emerging technologies into the clinical environment.  The Young Investigators Symposium is a competition for new researchers in honor of Dr. John Cameron.  The Young Investigators and Best Poster Winners are shown here:

 

Jiang & Gitajn win SYNERGY translational pilot funds

Together with Dr. Leah Gitajn, Assistant Professor in Orthopaedic Surgery, Shudong Jiang, PhD won a 2018 pilot grant from the Dartmouth SYNERGY program for their project “A Pilot Study Evaluating Bone and Tissue Perfusion and Oxygen Tension in the Setting of Extremity Fracture.” Their project was one of five selected out of 27 preliminary proposals entered. The grant program fosters collaboration among researchers in basic science, translational research, and health services.

The SYNERGY Translational Pilot Grant Program funds innovative interdisciplinary research with clear potential for translation into patient-oriented care and improved population health, and is coordinated at the Dartmouth SYNERGY Clinical and Translational Science Institute.

2017 Awardees with ties to the Optics in Medicine program are:

  1. Scott Davis, PhD (Assistant Research Professor, Engineering/Thayer) and Kimberley Samkoe, PhD (Assistant Research Professor, Surgery; Adjunct Assistant Professor, Engineering/Thayer) for their project “Bio-slice: Whole-body, High-resolution 3-D Biodistribution Imaging of Multiple Agents.”
  2. Geoffrey Luke, PhD (Assistant Professor, Engineering/Thayer) and Lesley Jarvis, MD, PhD (Associate Professor, Medicine) for their project “Ultrasound Image-Guided Delivery of Oxygen-Carrying Nanoparticles for Radiation Therapy.”

NCCC funds pilot on fluorescence-guided surgery in ovarian cancer

Senior leaders at the Norris Cotton Cancer Center (NCCC) committed funding for a surgical research initiative by Thayer PI Jonathan T. Elliott, PhD with Professor Keith Paulsen, PhD, and clinical partner Evelyn Fleming, MD.  The proposal is titled, “Activation of Clinical Trial Investigating the Use of ABY-029 Fluorescence Guided Surgery in Ovarian Cancer” and is a strong translational initiative to address an important clinical problem in ovarian cancer – identifying patients whose ovarian cancer is not widespread and are thus good candidates for surgery.

The new project will build on two on-going clinical studies using ABY-029 (a Dartmouth-developed EGFR-targeted fluorophore) to examine  whether this molecule can be used to discriminate between normal and cancerous tissue during brain glioma and sarcoma fluorescence-guided resection.

Samkoe molecular imaging paper featured at WMIC Highlight Seminar

Kimberley Samkoe, PhD, was honored to have her conference abstract chosen for presentation at the Highlight Lecture that kicked off the September 2017 World Molecular Imaging Congress (WMIC) in Philadelphia.

The paper was entitled, “Quantitative molecular imaging of intracellular signaling in an in ovo avatar model of pancreatic cancer for predicting personalized response to molecular therapies within one week of laparoscopic biopsy.”  Dr. Samkoe presented the clinical and laboratory research and findings of the study she led with colleagues from the Illinois Institute for Technology and the Oregon Health and Science University.  

In the study, human tumor lines were used to produce in ovo avatars and to develop and validate a rapid, in vivo assay that predicts therapy efficacy outcomes through changes in intracellular signaling proteins for individual patients.  Dr. Samkoe and her research partners believe this model will be substantially faster and more cost effective than traditional patient-derived xenograft mouse models.