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NIBIB funds radiotherapy Cherenkov calibration project

Thayer & Geisel researchers are excited to have won a four year NIBIB R01 grant entitled “Optical Cherenkov Calibration for Human Radiation Therapy” that builds upon a fundamental technological discovery made at Dartmouth, and patented into a translational technology, by Professors Pogue, Gladstone and Jarvis along with PhD students Adam Glaser & Rongxiao Zhang.

Researchers in the Medical Physics Program at Dartmouth have used optical imaging of Cherenkov emissions to map the radiation dose deRadiation Therapylivered to tissue. This the first time ever that radiation dose delivered to tissue has been directly imaged with high spatial and temporal resolution.  Their approach represents a complete paradigm change in how radiation therapy is documented and archived for both real time control and quality audits.

Professor Pogue remarked, “From a practical standpoint, using optical technology to image Cherenkov emissions is significantly simpler than most dosimetry tools currently available to clinicians. The challenge is to maintain quantitative accuracy in order to be competitive in documenting the dose delivered to tissue.”

Through pilot studies of breast cancer patients undergoing radiotherapy, the grant project will advance methods to correct for tissue curvature and tissue optical properties, two of the most dominant factors that alter the linear relationship between dose and Cherenkov emission. Researchers will focus on reducing errors in alignment of patients for daily treatments by using Cherenkov imaging to verify the combined on-patient delivery of the beam, using vascular patterns of the breast that are visible in treatment beam images.  The team will also explore the similarity of Cherenkov intensity to thermoluminescent diode measurement, to determine if this solution is more accurate and easier to implement.

This study is being conducted in partnership with leading companies that are advancing the methods for patient surface scanning, tissue optical property imaging and Cherenkov imaging system development, ensuring that the discoveries made can be translated into a commercial venture.

The team is actively looking to recruit researchers in Medical Physics or Electrical Engineering to work on this project, and expects to use this funding to support several Thayer PhD students in the coming years.

Dartmouth Wins FDA Approval for New Fluorescent Agent to Guide Cancer Surgery

In a major milestone for Dartmouth and for the future of molecular guided cancer surgery, Dartmouth has gained FDA approval for a study that may give surgeons a new “guiding light” during cancer surgeries.  The approval gives Dartmouth the go-ahead for the first study involving humans of a fluorescent agent for guiding tumor surgery.  The agent, called ABY-029, binds to cancer cell receptors and highlights tumors during surgery.   Production of ABY-029 was coordinated by Dartmouth’s Thayer School of Engineering and Geisel School of Medicine, with Academic-Industrial partners Affibody AB, LI-COR Biosciences, and the University of Alabama at Birmingham using NCI grant funding.

thayer-paulsen-pritzker-8101“Our approach will dramatically accelerate the paradigm shift towards molecular guided surgical oncology,” says Keith Paulsen, the Robert A. Pritzker Professor of Biomedical Engineering and scientific director of Dartmouth’s Center for Surgical Innovation.

Read the full story at http://news.dartmouth.edu/news/2016/10/dartmouth-wins-fda-approval-aid-guide-cancer-surgery

New Lab for Optics in Medicine


The Thayer School of Engineering at Dartmouth has purchased laboratory space at the new Williamson Translational Research Building, located at Dartmouth-Hitchcock Medical Center.

Approximately nine Principal Investigators and their research teams share this contemporary open-concept lab, hosting post-doctoral researchers from many countries and teaching Thayer graduate and undergraduate students.  The substance of ongoing biomedical research at each bench varies widely, from ultrasound, optics and nanotechnology, to prosthetic devices, bioimpedance and cancer diagnosis and treatment.

Co-location of Thayer School Investigators with Clinicians at DHMC through this move to the Williamson building has proven invaluable to bringing about translational research, allowing the exchange of novel ideas and the advancement of technology innovation and development.

Here the Optics in Medicine group meets regularly to review progress on research projects.


Animal studies are carried out in the small animal surgery room.




Two Tissue Culture rooms enable tumor research to progress.




In celebration of our move to this new space and the 2015 holiday season, Optics in Medicine faculty, staff and researchers enjoyed lunch at Jesse’s restaurant.