COURSES IN PHARMACOLOGY AND TOXICOLOGY
122. Neuropharmacology
08F: Arrange Offered in alternate years
The course will provide both didactic lectures and small group journal club sessions. It will focus on pharmacological mechanisms of drugs that effect the nervous system with teaching expertise from Neurology, Psychiatry, Anesthesiology and Pharmacology. Open to all graduate students and upper level undergraduates (with permission from the course directors). Course Directors: J. DeLeo, A. Green.
123. Graduate Toxicology
08W: Arrange Offered in alternate years
This course is open to graduate, medical and advanced undergraduate students. It provides an introduction to toxicology as a discipline, with a focus on the molecular basis for toxicity of chemicals in biological systems. Major topics include: principles of cell and molecular toxicology, xenobiotic metabolism, molecular targets of cellular toxicity, genetic toxicology, chemical carcinogenesis, immunotoxicology, neurotoxicology, clinical toxicology, and quantitative risk assessment.
Faculty lectures and discussion. Prerequisite: Undergraduate or graduate biochemistry, or permission of instructor. Instructors: Hamilton (course director) and others.
124. Ethical Conduct of Research (Identical to Physiology 124)
07F: Arrange Offered every year
This course is required for all PEMM and MCB graduate students. There will be approximately four one-and a half hour small group discussion sessions and four one hour lectures with the times to be arranged. Topics will include: mentoring, data collection, academic integrity, ethical use of human subjects and laboratory animals, authorship, sponsored research and intellectual property.
Faculty lectures and discussion. Instructors: North, Green & DeLeo (course directors) and others.
126. Cancer Biology
09S: Arrange Offered in alternate years
This course will present a comprehensive survey of the biology, biochemistry, pharmacology, and genetics of cancer. Students will become familiar with such areas as cancer terminology, epidemiology, carcinogenesis, tumor promotion, metastasis, oncogenes, tumor suppressor genes, tumor viruses, growth factors, hormones, immunology, and therapy. Where possible, emphasis will be placed on the most recent cell and molecular aspects of cancer. The class will be in lecture format and meet for 3 hours each week.
Faculty lectures and discussion. Prerequisite: Graduate biochemistry, or permission of instructor. Instructors: Eastman (course director) and others.
129. Molecular Pharmacology
08S: Arrange Offered every year
The principles of ligand reactions with the receptors and the resulting changes in cellular signaling will be discussed in lecture format. Topics will include the cellular and molecular basis for pharmacologic selectivity, for receptor theory and kinetics, for specific receptor actions. Emphasis will be placed on recent developments in receptor biology and signaling cascades and on the methodologies required to study these processes. The course will meet 4 hours per week and course materials will include current literature reviews and research articles.
Faculty lectures and discussion. Prerequisite: permission of the instructor. Instructors: Robbins (course director) and others.
131. Current Approaches in Experimental Therapeutics
09W: Arrange Offered in alternate years
This course will present a survey of current methods and approaches in pharmacologic, molecular and experimental therapeutic research. Topics will include pharmacogenomics, pharmacokinetics, functional genomics, in vivo imaging, global gene expression, proteomics, gene targeting, gene therapy and drug screening and delivery. The class will be in lecture format with student discussion and participation. The class will meet for 3 hours each week.
Faculty lectures and discussion. Prerequisite: permission of instructor. Instructors: Spinella and DiRenzo (course directors) and others.
137. Project Research (Qualifying Examination)
All terms: Arrange
141. Research Rotation 1
All terms: Arrange
142. Research Rotation 2
All terms: Arrange
143. Research Rotation 3
All terms: Arrange
216/217. Medical Pharmacology
DMSII calendar (terms 1-5) Offered every year
The major, conceptual modules are general principles, pharmacology of autonomic and central nervous system, cardiovascular pharmacology, endocrine and autacoid pharmacology, chemotherapy, and toxicology. Instruction is primarily through classroom lectures (67 hours) with three small group sessions on clinical pharmacology in Terms I and II. Emphasis is placed on understanding the dynamic mechanisms by which drugs modify normal biochemical or physiological functions and how they correct pathophysiological disturbances of those functions.
Faculty lectures and small group facilitators. Prerequisite: permission of instructor. Instructors: Hwa (course director) and others.
297. Level I: part-time research: 1 course equivalent
All terms: Arrange
298. Level II: part-time research: 2 course equivalent
All terms: Arrange
299. Level III: full-time thesis research: 3 course equivalent
All terms: Arrange