Jennifer Wei Zou, Ph.D., DABR Assistant ProfessorDepartment of Radiation OncologyUniversity of Pennsylvania
Abstract:FLASH radiotherapy refers to the radiation beams being delivered at ultra-high dose rates. Multiple biological experiments have found that FLASH beams resulted in dose-sparing in normal tissues while maintaining similar tumor-killing effects when compared to the conventional beam deliveries. In this talk, I will discuss several developmental FLASH projects in Penn. I will discuss a thin-gap monitoring ion chamber used to characterize our cyclotron-based proton FLASH pencil beams. In proton pencil beam scanning delivery, the dose is built up through the spot matrix in the field. I will show that FLASH dose rate is hard to achieve for the entire field larger than 4×4 cm^2, but a percentage of the total dose can be delivered at an ultra-high dose rate. Lastly, I will discuss our effort to simulate a FLASH mechanism based on oxygen depletion assumption correlated to the tissue local vasculature structures.
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