Publications

Allaway RJ, Wood M, Downey S, Bouley SJ, Traphagan N, Wells J, Batra J, Melancon SNT, Ringelberg C, Seibel W, Ratner N, and Sanchez Y. Exploiting mitochondrial and metabolic homeostasis as a vulnerability in NF1 deficient cells. Oncotarget. 2017 July 18. doi: 10.18632/oncotarget.19335 

Way GP*, Allaway RJ*, Bouley SJ, Fadul CE, Sanchez Y, and Greene CS. A machine learning classifier trained on cancer transcriptomes detects NF1 inactivation signal in glioblastoma. BMC Genomics. 2017 Feb 6. 18: 127. doi:10.1186/s12864-017-3519-7. PubMed ID: 5292791  * = Equal Contribution

Allaway RJ*, Fischer DA*, Gardner TB, Gordon SR, Barth RJ, Colacchio TA, Kacsoh BZ, de Abreu FB, Peterson JD, Choi JA, Tomlinson CR, Tsongalis GJ, Padmanabhan V, Suriawinata AA, Greene CS, Sanchez Y, and Smith K. Fine-needle biopsy patient-derived xenografts as tools for drug discovery and individualized therapy for pancreatic cancer.  Oncotarget. 2016 Feb 25. doi: 10.18632/oncotarget.7718. PubMed  ID: 26934555 * = Equal Contribution

Cortez D, Zhou Z, and Sanchez Y. Stephen Elledge and the DNA Damage Response. DNA Repair. 2015. 35: 156-157. PubMed ID: 26574138

Searle JS, Wood M,  Kaur M, Tobin DV and Sanchez Y.  Proteins in the nutrient sensing and DNA damage checkpoint pathways cooperate to restrain mitotic progression following DNA damage.  PLOS Genetics. 2011 Jul. 7(7): e1002176. PubMed ID: 21779180

Wood MD, Rawe M, Johansson G, Pang S, Soderquist R, Patel A, Nelson S, Seibel W, Ratner N, and Sanchez Y.  Discovery of a small molecule targeting IRA2deletion in budding yeast and neurofibromin loss in malignant peripheral nerve sheath tumor cells.  Molecular Cancer Therapeutics. Jun 22. 2011. PubMed ID: 21697395

Wood MD. and Sanchez Y.  2010. Deregulated Ras signaling compromises DNA damage checkpoint recovery in S. cerevisiae. Cell Cycle. 2010 Aug 17. 9(16). PubMed ID: 20716966

Pereira E, Chen Y. and Sanchez Y. Conserved ATRMec1 phosphorylation-independent activation of Chk1 by single amino acid substitution in the GD domain. Cell Cycle, 2009 Jun 1. 8(11): 1788-93. PubMed ID: 19411848

Chen Y, Caldwell JM, Pereira E, Baker RW, and Sanchez Y.  ATRMec1 phosphorylation-independent activation of Chk1 in vivo.  J. Biol. Chem., 2009. 284 (1), 182-190. PubMed ID: 18984588

Carrassa L, Sanchez Y, Erba E, and Damia G.  U20S Cells Lacking Chk1 undergo aberrant mitosis and fail to activate the spindle checkpoint.  J. Cell Mol. Med. 2008. PubMed ID: 19778378

Caldwell JM, Chen Y, Schollaert KL, Theis JF, Babcock GF, Newlon CS, and Sanchez Y. Orchestration of the S-phase and DNA-damage checkpoint pathways by replication forks from early origins. J. Cell Biol. 2008 Mar 24: 180(6): 1073-86. PubMed ID: 18347065

Schollaert KL, Poisson JM, Searle JS, Schwanekamp JA, Tomlinson CR, and Sanchez Y.  A novel role for Saccharomyces cerevisiae Chk1p in the response to replication blocks.  Mol. Biol. Cell. 2004. 15(9). PubMed ID: 15229282

Rogoff HA, Pickering MT, Frame FM, Debatis ME, Sanchez Y, Jones S, and Kowalik TF. Apoptosis Associated with Deregulated E2F Activity is Dependent on E2F1 and Chk2. Mol Cell Biol. 2004. 24(7): 2968-2977. PubMed ID: 15024084

Searle JS, Schollaert KL, Wilkins B, and Sanchez Y. The DNA damage checkpoint and PKA pathways converge on APC substrates and Cdc20 to regulate mitotic progression. Nat Cell Biol. 2004 Feb: 6(2): 138-45. PubMed ID: 14743219

Goudelock DM, Jiang K, Pereira E, Russell B, and Sanchez Y.  Regulatory interactions between the checkpoint kinase Chk1 and the proteins of the DNA-PK complex. J. Biol. Chem. 2003 Aug 8. 278: 29940-29947. PubMed ID: 12756247

Jiang K, Pereira E, Maxfield M, Russell B, Goudelock DM, and Sanchez Y.  Regulation of Chk1 includes chromatin association and nuclear retention following phosphorylation on Ser345. J. Biol. Chem. 2003. 278(27): 25207-25217. PubMed ID: 12676962

Kuznetzova AV, Meller J, Schnell PO, Nash JA, Ignacal ML, Sanchez Y, Conaway JW, Conaway RC, and Czyzyk-Krzeska MF.  VHL tumor suppressor complex binds hyperphosphorylated large subunit of RNA Polymerase II through a proline hydroxylation motif and targets it for ubiquitination.  Proc. Natl. Acad. Sci. USA. 2003. 100:2606-2711. PubMed ID: 12604794

Bahassi E M, Conn, CW, Myer DL, Hennigan RF, McGowan CH, Sanchez Y, and Stambrook PJ. Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways. Oncogene. 2002. 21: 6633-6640. PubMed ID: 12242661

Damia G,  Sanchez Y, Erba E, and Broggini M.  DNA damage induces p53-dependent downregulation of hChk1.  J. Biol. Chem. 2001. 276(14): 10641-10645. PubMed ID: 11152453

Conn WC, Hennigan RF, Dai W, Sanchez Y, and Stambrook PJ.  Incomplete cytokinesis and induction of apoptosis by overexpression of the mammalian polo-like kinase, Plk3. Cancer Research. 2000. 60(24): 6826-6831. PubMed ID: 11156373

Sanchez Y, Bachant J, Wang H, Liu D, Hu F, Tezlaff M, and Elledge SJ.  Control of the DNA damage checkpoint by Chk1 and Rad53 protein kinases through distinct mechanisms. Science. 1999. 286(5442): p. 1166-71. PubMed ID: 10550056

Sanchez Y, Wong, C, Thoma RS, Richman R, Wu Z, Piwnica-Worms H, and Elledge SJ. Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA damage to Cdk regulation via Cdc25.  Science. 1997. 277: 1497-1501. PubMed ID: 9278511

Sanchez Y, Zhou Z, Huang M, Kemp BE, and Elledge SJ.  Analysis of Budding Yeast Kinases Controlled by DNA damage.  In Methods in Enzymology-Cell Cycle Control, 1997. vol 283. PubMed ID: 9251037

Navas TA, Sanchez Y, and Elledge SJ.  RAD9 and DNA polymerase E form parallel sensory branches for transducing the DNA damage checkpoint signal in S.cerevisiae.  Genes and Dev. 1996. 10: 2632-2643. PubMed ID: 8895664

Sanchez Y, Lovell M, Marin MC, Wong P, Wolf E, McDonnell TJ, and Killary AM.  Tumor suppression and apoptosis of human prostate carcinoma mediated by a genetic locus within human chromosome 10pter-q11.  Proc. Natl. Acad. Sci. USA. 1996. 93: 2551-2556. PubMed ID: 8637912

Sanchez Y. Desany B, Jones WJ, Liu Q, Wang B, and Elledge SJ.  Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in Yeast Cell Cycle Checkpoint Pathways.  Science. 1996. 271:357-360. PubMed ID: 8553072

Killary AM, Lott ST, and Sanchez Y.  Functional Studies to Identify Tumor Suppressor Genes.  METHODS: A companion to Methods in Enzymology. 1995. v8: 234-246.

Sanchez Y and Elledge SJ.  Stopped for Repairs. Bioessays, 17(6):545-548, 1995. PubMed ID: 7575496

Sanchez Y, El-Naggar A, Pathak S, and Killary AM.  A tumor suppressor locus within human chromosome 3p14-3p12 mediates rapid cell death of renal cell carcinoma in vivo.  Proc. Natl. Acad. Sci. USA, 1994. 91:3383-3387. PubMed ID: 8159756

Sharp ZD, Helsel S, Cao Z, Barron EA, and Sanchez Y.  DNA recognition element required for PUF-1 mediated cell-type-specific transcription of the rat prolactin gene.  Nucl. Acids, Res., 1989.17:2705-2722. PubMed ID: 2717408