Pubmed Publication:
Manually Updated:
Cho, J., Costa, S. K., Wierzbicki, R. M., Rigby, W. F., & Cheung, A. L. "The extracellular loop of the membrane permease VraG interacts with GraS to sense cationic antimicrobial peptides in Staphylococcus aureus." PLoS pathogens. 2021
Li L, Bayer AS, Cheung A, Lu L, Abdelhady W, Donegan NP, Hong JI, Yeaman MR, Xiong YQ. The stringent response contributes to persistent methicillin-resistant Staphylococcus aureus endovascular infection through the purine biosynthetic pathway. The Journal of Infectious Diseases 2020
Ma D, Mandell JB, Donegan NP, Cheung AL, Ma W, Rothenberger S, Shanks RMQ, Richardson AR, Urish KL. The Toxin-Antitoxin MazEF Drives Staphylococcus aureus Biofilm Formation, Antibiotic Tolerance, and Chronic Infection. mBio. 2019
Limoli DH, Warren EA, Yarrington KD, Donegan NP, Cheung AL, O'Toole G. Interspecies interactions induce exploratory motility in Pseudomonas aeruginosa . Elife. 2019
Donegan NP, Manna AC, Tseng CW, Liu GY, Cheung AL. CspA regulation of Staphylococcus aureus carotenoid levels and σ activity is controlled by YjbH and Spx. Molecular Microbiology 2019
Mikheyeva IV, Thomas JM, Kolar SL, Corvaglia AR, Gaϊa N, Leo S, Francois P, Liu GY, Rawat M, Cheung AL. YpdA, a putative bacillithiol disulfide reductase, contributes to cellular redox homeostasis and virulence in Staphylococcus aureus. Mol Microbiol. 2019
Manna AC, Kim S, Cengher L, Corvaglia A, Leo S, Francois P, Cheung AL. Small RNA Teg49 is derived from a sarA transcript and regulates virulence genes independent of SarA in Staphylococcus aureus. Infection and Immunity 2018
Nair DR, Chen J, Monteiro JM, Josten M, Pinho MG, Sahl HG, Wu J, Cheung A. A quinolinol-based small molecule with anti-MRSA activity that targets bacterial membrane and promotes fermentative metabolism. J Antibiot (Tokyo). 2017
Falahee PC, Anderson LS, Reynolds MB, Pirir M, McLaughlin BE, Dillen CA, Cheung AL, Miller LS, Simon SI. α-Toxin Regulates Local Granulocyte Expansion from Hematopoietic Stem and Progenitor Cells in Staphylococcus aureus-Infected Wounds. J Immunol. 2017
Costa SK, Donegan NP, Corvaglia AR, François P, Cheung AL. Bypassing the Restriction System To Improve Transformation of Staphylococcus epidermidis. J Bacteriol. 2017
Li L, Cheung A, Bayer AS, Chen L, Abdelhady W, Kreiswirth BN, Yeaman MR, Xiong YQ. The Global Regulon sarA Regulates β-Lactam Antibiotic Resistance in Methicillin-Resistant Staphylococcus aureus In Vitro and in Endovascular Infections. J Infect Dis. 2016
Springer MT, Singh VK, Cheung AL, Donegan NP, Chamberlain NR. Effect of clpP and clpC deletion on persister cell number in Staphylococcus aureus. J Med Microbiol. 2016
Conlon BP, Rowe SE, Gandt AB, Nuxoll AS, Donegan NP, Zalis EA, Clair G, Adkins JN, Cheung AL, Lewis K. Persister formation in Staphylococcus aureus is associated with ATP depletion. Nat Microbiol. 2016
Chaili S, Cheung AL, Bayer AS, Xiong YQ, Waring AJ, Memmi G, Donegan N, Yang SJ, Yeaman MR. The GraS Sensor in Staphylococcus aureus Mediates Resistance to Host Defense Peptides Differing in Mechanisms of Action. Infect Immun. 2016
Tuchscherr L, Bischoff M, Lattar SM, Noto Llana M, Pförtner H, Niemann S, Geraci J, Van de Vyver H, Fraunholz MJ, Cheung AL, Herrmann M, Völker U, Sordelli DO, Peters G, Löffler B. Sigma Factor SigB Is Crucial to Mediate Staphylococcus aureus Adaptation during Chronic Infections. PLoS Pathog. 2015
Nair DR, Monteiro JM, Memmi G, Thanassi J, Pucci M, Schwartzman J, Pinho MG, Cheung AL. Characterization of a novel small molecule that potentiates β-lactam activity against gram-positive and gram-negative pathogens. Antimicrob Agents Chemother. 2015
Jones MJ, Donegan NP, Mikheyeva IV, Cheung AL. Improving transformation of Staphylococcus aureus belonging to the CC1, CC5 and CC8 clonal complexes. PLoS One. 2015
Cheung AL, Bayer AS, Yeaman MR, Xiong YQ, Waring AJ, Memmi G, Donegan N, Chaili S, Yang SJ. Site-specific mutation of the sensor kinase GraS in Staphylococcus aureus alters the adaptive response to distinct cationic antimicrobial peptides. Infect Immun. 2014
Donegan NP, Marvin JS, Cheung AL. Role of adaptor TrfA and ClpPC in controlling levels of SsrA-tagged proteins and antitoxins in Staphylococcus aureus. J Bacteriol. 2014
Sully EK, Malachowa N, Elmore BO, Alexander SM, Femling JK, Gray BM, DeLeo FR, Otto M, Cheung AL, Edwards BS, Sklar LA, Horswill AR, Hall PR, Gresham HD. ive chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance. PLoS Pathog. 2014
Zorzini V, Buts L, Sleutel M, Garcia-Pino A, Talavera A, Haesaerts S, De Greve H, Cheung A, van Nuland NA, Loris R. Structural and biophysical characterization of Staphylococcus aureus SaMazF shows conservation of functional dynamics. Nucleic Acids Res. 2014
Abdelhady W, Bayer AS, Seidl K, Moormeier DE, Bayles KW, Cheung A, Yeaman MR, Xiong YQ. Impact of vancomycin on sarA-mediated biofilm formation: role in persistent endovascular infections due to methicillin-resistant Staphylococcus aureus. J Infect Dis. 2014
Posada AC, Kolar SL, Dusi RG, Francois P, Roberts AA, Hamilton CJ, Liu GY, Cheung A. Importance of bacillithiol in the oxidative stress response of Staphylococcus aureus. Infect Immun. 2014
Guo Y, Ramos RI, Cho JS, Donegan NP, Cheung AL, Miller LS. In vivo bioluminescence imaging to evaluate systemic and topical antibiotics against community-acquired methicillin-resistant Staphylococcus aureus-infected skin wounds in mice. Antimicrob Agents Chemother. 2013
Cho JS, Guo Y, Ramos RI, Hebroni F, Plaisier SB, Xuan C, Granick JL, Matsushima H, Takashima A, Iwakura Y, Cheung AL, Cheng G, Lee DJ, Simon SI, Miller LS. Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice. PLoS Pathog. 2012
Priest NK, Rudkin JK, Feil EJ, van den Elsen JM, Cheung A, Peacock SJ, Laabei M, Lucks DA, Recker M, Massey RC. From genotype to phenotype: can systems biology be used to predict Staphylococcus aureus virulence?. Nat Rev Microbiol. 2012
Cheung A, Duclos B. Stp1 and Stk1: the Yin and Yang of vancomycin sensitivity and virulence in vancomycin-intermediate Staphylococcus aureus strains. J Infect Dis. 2012
Berscheid A, Sass P, Weber-Lassalle K, Cheung AL, Bierbaum G. Revisiting the genomes of the Staphylococcus aureus strains NCTC 8325 and RN4220. Int J Med Microbiol. 2012
Pribaz JR, Bernthal NM, Billi F, Cho JS, Ramos RI, Guo Y, Cheung AL, Francis KP, Miller LS. Mouse model of chronic post-arthroplasty infection: noninvasive in vivo bioluminescence imaging to monitor bacterial burden for long-term study. J Orthop Res. 2012
Memmi G, Nair DR, Cheung A. Role of ArlRS in autolysis in methicillin-sensitive and methicillin-resistant Staphylococcus aureus strains. J Bacteriol. 2012
Yang SJ, Bayer AS, Mishra NN, Meehl M, Ledala N, Yeaman MR, Xiong YQ, Cheung AL. The Staphylococcus aureus two-component regulatory system, GraRS, senses and confers resistance to ed cationic antimicrobial peptides. Infect Immun. 2012
Jens Abel, Oliver Goldmann, Christina Ziegler, Claudia Höltje, Mark S. Smeltzer, Ambrose L. Cheung, Daniela Bruhn, Manfred Rohde and Eva Medina. 2011. Staphylococcus aureus evades the extracellular antimicrobial activity of Mast cells by promoting its own uptake. J. Innate Immunity.
Lucía P. Alvarez, María S. Barbagelata, Mariana Gordiola, Ambrose L. Cheung, Daniel O. Sordelli and Fernanda R. Buzzola. 2011. Salicylic Acid Enhances Staphylococcus aureus Extracellular Adhesion Protein (Eap) Expression. Microbes and Infection. Accepted.
Oana Dumitrescu , Sandrine Boisset, Cédric Badiou, Michele Bes, Yvonne Benito, François Vandenesch, Jerome Etienne, Ambrose L Cheung and Gerard Lina. 2011. Beta-lactams interfering with PBP1 induce Panton-Valentine leukocidin expression by triggering SarA and rot global regulators of Staphylococcus aureus. AAC. Accepted.
Zorzini V, Haesaerts S, Donegan NP, Fu Z, Cheung AL, van Nuland NA, Loris R. 2011. Crystallization of the S. aureus MazF mRNA interferase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 67:386-389.
Dindo Reyes, Diego Andrey, Antoinette Monod, William L. Kelley, Gongyi Zhang and Ambrose L. Cheung. 2011. The interactions of AgrA, SarA, SarR at the agr promoter interface in S. aureus. J. Bacteriol. Accepted.
Dhanalakshmi Nair, Guido Memmi, David Hernandez, Jonathan Bard, Steven Gill, Patrice Francois and Ambrose L. Cheung. 2011. Whole genome sequencing of Staphylococcus aureus strain RN4220, a key laboratory strain used in virulence research, identifies mutations that affect not only virulence factors but also the fitness of the strain. J. Bacteriology. 193:2332-2335.
Zorzini V, Haesaerts S, Cheung A, Loris R, van Nuland NA. 2011. (1)H, (13)C, and (15)N backbone and side-chain chemical shift assignment of the staphylococcal MazF mRNA interferase. Biomol NMR. Accepted.
John S. Cho, Jamie Zussman, Niles P. Donegan, Romela Irene Ramos, Nairy C. Garcia, Daniel Z.Uslan, Yoichiro Iwakura, Scott I. Simon, Ambrose L. Cheung, Robert L Modlin, Jenny Kim, and Lloyd S. Miller. 2011. Noninvasive in vivo imaging to evaluate immune responses and antimicrobial therapy against Staphylococcus aureus and USA300 MRSA skin infections. J. Invest. Dermatol. Accepted.
Nicholas M. Bernthal, Alexandra I. Stavakis, Fabrizio Billi, John S. Cho, Thomas J. Kremen, Daniel Z. Uslan, Qing Ge, Satish Pulapura4, Arikha Moses, Scott I. Simon, Ambrose L. Cheung, Jay R. Lieberman, Gerald A. Finerman, John S. Adams and Lloyd S. Miller. 2010. A novel mouse model of post-arthroplasty joint infection to evaluate the in vivo efficacy of antimicrobial implant coatings. PLoS One 5:e12590. PMCID: PMC2935351
Sandeep Tamber, D. Reyes, J. D. Schwartzman, A.L. Cheung and Guido Memmi. 2010. The staphylococcal specific gene, rsr, represses agr and virulence in S. aureus. Infect. Immun. 78:4384-4391. PMCID: PMC2950337
Diego O. Andrey, Antoinette Monod, Ambrose L. Cheung, and William L. Kelley. 2010. Control of the Staphylococcus aureus/ toxic shock TSST-1 tst promoter by the global regulator SarA. J. Bacteriology. 192:6077-85.
Sandeep Tamber, J. D. Schwartzman and A.L. Cheung. 2010. The role of PknB kinase in antibiotic resistance and virulence in community acquired MRSA strain USA300. Infect. Immun. 78: 3637–3646. PMCID: PMC291626
John S. Cho, Eric M. Pietras, David M. Farzam, Holly R. Monroe, Julie E. Magorien, Nairy C. Garcia, Nico P. Ghilardi, Jay K. Kolls, Ambrose L. Cheung, Genhong Cheng, Robert L. Modlin, and Lloyd S. Miller. 2010. IL-17-producing epidermal gamma and delta T cells are required for innate immunity against Staphylococcus aureus. JCI. 120:1762-1773. PMCID: PMC2860944
Lucía P. Alvarez, María S. Barbagelata, Ambrose L. Cheung, Daniel O. Sordelli and Fernanda R. Buzzola. 2010. Salicylic Acid diminishes Staphylococcus aureus capsular polysaccharide type 5 expression. Infection and Immunity. 78:1339-44. PMCID: PMC2825945
Niles P. Donegan and Ambrose L. Cheung. 2010. Degradation of the mazE antitoxin by ClpCP in Staphylococcus aureus. J. Bacteriol. 192:1416-22. PMCID: PMC2820870
Adriana Renzoni, William L. Kelley, Pierre Vaudaux, Ambrose Cheung and Daniel P. Lew. 2010. Exploring innate mechanisms of glycopeptide resistance in Staphylococcus aureus. Trends in Microbiology. 18:55-56. PMID: 20005114.
M Pilar Trotonda, M Pilar Trotonda, Miguel Martí, M Ángeles Tormo, Marta Vergara-Irigay, Ambrose L. Cheung, Iñigo Lasa, José R. Penadés. 2010. Extracellular proteases inhibit protein-dependent biofilm formation in Staphylococcus aureus. Microbes and Infection. 12:55-64. PMID: 19883788.
Eric Carnes, Carlee Ashley, DeAnna Lopez, Hattie Gresham, Ambrose Cheung, Graham S Timmins, and CJ Brinker. 2010. A Quorum of One (Discrete Quorum Sensing as Environmental Sensing). Nature Chem. Biol. 6: 41-5. PMID: 19935660.
Ambrose L. Cheung, Soo-Jing Yang, Arnold S. Bayer and Yan Q. Xiong. 2009. Disparity In the in vitro vs. in vivo regulation of fibronectin-binding proteins (FnBPs) by saeRS and/or sigB, two global regulators of virulence determinants, in Staphylococcus aureus. JID. 200:1371-1374.
Lauderdale, K. J., B. R. Boles, A. L. Cheung, and A. R. Horswill. 2009. Interconnection between Sigma B, agr and proteolytic activity in Staphylococcus aureus biofilm maturation. Infect. Immun. 77: 1623–1635.
Niles P. Donegan and Ambrose L. Cheung. 2009. Regulation of the mazEF toxin-antitoxin module in Staphylococcus aureus and its impact on sigB expression. J. Bacteriol. 191:2795-2805.
Fu, Z., S. Tamber, G. Memmi, N. P. Donegan and A. L. Cheung. 2009. Over-expression of MazFsa induces bacteriostasis with essential mRNA protected in Staphylococcus aureus. J. Bacteriol. 191:2051-2059.
María Pilar Trotonda, Yan Q. Xiong, Arnold S. Bayer and Ambrose L. Cheung. 2009. The role of mgrA and sarA in autolysis and resistance to cell-wall active antibiotics in methicillin resistant S. aureus. J. Infect. Dis. 199:209-18.
Tamber, S. and A. L. Cheung. 2009. SarZ promotes the expression of virulence factors and represses biofilm formation by modulating SarA and agr in Staphylococcus aureus. Infect. Immun. 77: 419–428
M. Michal Peterson, Jessica L. Mack, Anny A. Alsup, Susan M. Alexander, Youhanna S. Sawires, Aldons J. Lusis, Ambrose L. Cheung, and Hattie D. Gresham. 2008. Apolipoprotein B is an Innate Barrier Against Invasive Staphylococcus aureus Infection. Cell Host and Microbes. 4(6):555-566.
Maren von Köckritz-Blickwede, Manfred Rohde, Sonja Oehmcke, Lloyd S. Miller, Ambrose L. Cheung, Heiko Herwald, Simon Foster, and Eva Medina. 2008. Immunological Mechanisms Underlying the Genetic Predisposition to Severe Staphylococcus aureus Infection in the Mouse Model. American Journal of Pathology. 173(6):1657-68.
Maria P. Trotonda, Sandeep Tamber, Guido Memmi and Ambrose L. Cheung. 2008. MgrA represses biofilm formation in Staphylococcus aureus. Infect. Immun. 76: 5645–5654.
Guido Memmi, Sergio R. Filipe, Mariana G. Pinho, Ambrose Cheung. 2008. Staphylococcus aureus PBP4 is essential for β-lactams Resistance in Community Acquired Methicillin Resistant Strains. Antimicro. Agents Chemo. 52:3955-3966.
Jarry, T. and Cheung, A.L. 2008. The expression of alpha hemolysin is sufficient for S. aureus phagosomal escape after internalization in CFT-1 cells. Cellular Microbiology. 10:1801–1814
Robert M. Q. Shanks, Michael Meehl, Kimberly M. Brothers, Raquel M. Martinez, Niles P. Donegan, Martha L. Graber, Ambrose L. Cheung and George A. O’Toole. 2008. Genetic Evidence for an Alternative Citrate-Dependent Biofilm Formation Pathway in Staphylococcus aureus That Is Dependent on Fibronectin Binding Proteins and the GraRS Two-Component Regulatory System. Infect. Immun. 76:2469-2477.
Cheung, A.L., K. Nishina, and A. C. Manna. 2008. SarA binds to its own promoter to regulate gene expression. J. Bacteriol. 190:2239-2243.
Dongmei Li and Cheung, A.L. 2008. The repression of hla by rot is dependent on sae in Staphylococcus aureus. Infect. Immun. 76:1068-1075.
Min-Ho Kim, Wei Liu, Dori L. Borjesson, Fitz-Roy E. Curry, Lloyd S. Miller, Ambrose L. Cheung, Fu-Tong Liu, R.R. Isseroff and Scott I Simon. 2008. Dynamics of neutrophil infiltration during cutaneous wound healing and infection using fluorescence imaging. J.Invest.Dermatol. 128:1812-20.
Cheung, A.L., K. Nishina, M. P. Trotonda and S. Tamber. 2008. Review of the SarA protein family. International Journal of Biochemistry and Cell Biology. 40:355-361.
Zhibiao Fu, Niles Donegon, Guido Memmi and Ambrose L Cheung. 2007. Characterization of MazF-sa, an endoribonuclease from Staphylococcus aureus. J. Bacteriol. 189:8871-8879.
Miller, L.S., Pietras, E.M., Uricchio, L. H., Hirano, K., Rao, S., Lin, H., O’Connell, R. M., Iwakura, Y., Cheung, A.L., Cheng, G., and Modlin, R.L. 2007. Inflammasome-mediated production of Il-1β is required for neutrophil recruitment against Staphylococcus aureus. J. Immunol. 179:6933-42
Silvia Herbert, Agnieszka Bera, Christiane Nerz, Dirk Kraus, Andreas Peschel, Christiane Goerke, Michael Meehl, Ambrose Cheung, Friedrich Götz. 2007. Molecular basis of resistance to lysozyme's muramidase and antimicrobial peptide activity in staphylococci. Plos Pathogens. 3:981-994.
Martina Ulrich, Mike Bastian, Katrin Ziegler, Sarah E. Cramton, Alexa A. Pragman, Alessandra Bragonzi, Guido Memmi, Christiane Wolz, Patrick M. Schlievert, Ambrose Cheung and Gerd Döring. 2007. The staphylococcal respiratory response regulator SrrAB induces ica gene transcription and PIA expression, protecting Staphylococcus aureus from neutrophil killing under anaerobic growth conditions. Mol. Microbiol. 65:1276-1287.
T. Kielian, N. Esen, A. Haney, N.K. Phulwani, P.M. Hayes, A.L. Cheung and J.J. Ruhe. 2007. Minocycline modulates neuroinflammation independent of its antimicrobial activity in S. aureus-induced brain abscess. 2007. Amer. J. Path. 171:1199-1214.
M. Meehl, Herbert, S., Götz, F. and Cheung, A. L. 2007. Interaction of the GraRS two-component system with the VraFG ABC-transporter to support vancomycin-intermediate resistance in Staphylococcus aureus. Antimicrob. Agents. Chemo. 51:2679-2689.
M. Sedlacek , Gemery, J.M., Cheung, A.L., Bayer, A.S. and Remillard, B.D. 2007. Aspirin treatment is associated with a significantly decreased risk of Staphylococcus aureus bacteremia in hemodialysis patients with tunneled catheters. Amer. J. Digest. Kidney Dis. 49:401-408.
M. Palma, A. S. Bayer, L. I. Kupferwasser, T. Yoska, M. R. Yeaman and A.L. Cheung. 2006. Salicylic acid activates sigma factor B by rsbU-dependent and –independent mechanisms. J. Bacteriol. 188:5986-5903.
Yan Q. Xiong, Julie Willard, Cynthia C. Nast, Michael R. Yeaman, Ambrose L. Cheung and Arnold S. Bayer. 2006. Regulation of Staphylococcus aureus α-toxin protein and gene (hla) expression by agr, sarA and sae in vitro and in Experimental Infective Endocarditis. JID. 194: 1267-1275.
A. C. Manna and A. L. Cheung. 2006. Characterization of SarX, a negative regulator of agr and exoprotein synthesis, is activated by MgrA in S. aureus. J. Bacteriol. 188:4288-4299.
A. C. Manna and A. L. Cheung. 2006. Transcriptional regulation of the agr locus and the identification of DNA binding residues of the global regulatory protein SarR in Staphylococcus aureus. Mol. Microbiol. 60:1289-1901.
T. Jarry and A. L. Cheung. 2006. Staphylococcus aureus escapes more efficiently from the phagosome of a Cystic Fibrosis bronchial epithelial cell line than its normal counterpart. Infect. Immun. 74:2568-2577.
L. S. Miller, R. M. O’Connell, M. A. Gutierrez, A. Shahangian, C. E. Gross, J. Thirumala, A. L. Cheung, G. Cheng and R. L. Modlin. 2006. IL-1R/MyD88 signaling by resident skin cells is required for immunity against Staphylococcus aureus. Immunity. 24:79-91.
Y. Liu, A.C. Manna, C.-H. Pan, I. A. Kriksunov, D. J. Thiel, A. L. Cheung, and G. Zhang. 2006. Structure and function analyses of the global regulatory protein SarA from S. aureus. PNAS. 103:2392-2397.
A. S. Bayer, P. McNamara, M. R. Yeaman, N. Lucindo, T. Jones, A. L. Cheung, H.-G. Sahl, and R. A. Proctor. 2006. Transposon Disruption of the Complex I NADH Oxido-Reductase Gene (snoD) in Staphylococcus aureus is Associated with Reduced Susceptibility to the Microbicidal Activity of Thrombin-induced Platelet Microbicidal Protein-1. J. Bacteriol. 188:211-222.
M. P. Trotonda, A. C. Manna, A. L. Cheung, I. Lasa, J. R. Penades. 2005. SarA controls Bap-dependent biofilm formation in Staphylococcus aureus. J. Bacteriol. 187:5790-5798.
R. M. Shanks, N. P. Donegan, M. L. Graber, S. A. Buckingham, M. E, Zegans, A. L. Cheung, and G. A. O’Toole. 2005. Heparin stimulates S. aureus biofilm formation. Infect. Immun. 73:4596-4606.
B. Haslinger-Löffler, Kahl, B.C., Strangfeld, K., Grundmeier, M., WagneR. B, Fischer. U., Cheung, A.L., Peters, G., Schulze-Osthoff, K., and Sinha, B. 2005. Multiple virulence factors are required for Staphylococcus aureus-induced apoptosis in endothelial cells. Cell. Microbiol. 7:1087-1097.
G. Belling, A. L. Cheung, G. Peters, M. Herrmann and B. Kahl. 2005. Thymidine-dependent Staphylococcus aureus small colony variants (SCV) are associated with dramatic changes in regulator and virulence gene expression. Infect. Immun. 734119-4126.
Cheung, A. L. and Manna, A.C. 2005. The role of the distal sarA promoters in SarA expression in Staphylococcus aureus. Infect. Immun. 73:4391-4394
Tormo, M.A., Marti, M., Valle, J., Manna, A.C., Cheung, A.L., Lasa,I., and Penades, J.R. 2005. SarA is an essential positive regulator of Staphylococcus epidermidis biofilm development. J. Bacteriol. 187:2348-2356.
Ingavale, S., van Wamel, W., Luong, T., Lee. C.Y., and Cheung, A.L. 2005. Rat/MgrA, a regulator of autolysis, is a regulator of virulence genes in Staphylococcus aureus. Infect. Immun. 73:1423-1431.
J. M. Rothfork, G. Timmins, M. N. Harris, X. Chen, A. L. Lusis, M. Otto, A. L. Cheung and H. D. Hattie. 2004. Inactivation of a bacterial virulence pheromone by phagocyte-derived oxidants: new role for the NADPH oxidase in host defense. PNAS. 101:13867-13872.
M. Gomez, A. Lee, B. Reddy, A. Muire, G. Soong, A. Pitt, A. L. Cheung, and A. Prince. 2004. Staphylococcus aureus protein A induces airway epithelial inflammatory responses by triggering TNFR1 and mimicking TNF-α activity. Nature Medicine. 10:842-848.
A. C. Manna, S.S. Ingavale, M. Maloney, W. van Wamel, and A.L. Cheung. 2004. Identification of sarV, a transcriptional regulator of the sarA family, is repressed by SarA and Rat and regulates autolysis and virulence genes in Staphylococcus aureus. J. Bacteriol. 186:5267-5280
K. A. Schmidt, N. P. Donegan, W. A. Kwan, Jr. and A.L. Cheung. 2004. Investigations into σB-Modulated Regulatory Pathways Governing Extracellular Virulence Determinant Production in Staphylococcus aureus. Can. J. Microbiol. 50:351-360.
Y.-Q. Xiong, A.S. Bayer, M.R. Yeaman, W. Van Wamel, A.L. Cheung. 2004. Impacts of sarA and agr in Staphylococcus aureus upon Fibronectin-Binding Protein A gene expression and fibronectin adherence capacity in vitro and in experimental infective endocarditis. Infect. Immun. 72:1832-1836.
Bisognano, C., Kelley,W., Francois, P., Schrenzel, J., Li, D. Estoppey, T., Lew, D.P., Hooper, D.C., Cheung, A.L. and Vaudaux, P. A. 2004. RecA-dependent pathway mediates ciprofloxacin-induced fibronectin-binding proteins in S. aureus. J. Biol. Chem. 279:9064-9071
Cheung, A.L., Bayer, A.S., Zhang, G., Gresham, H., and Xiong, Y.-Q. 2004. Regulation of virulence determinants in vitro and in vivo in Staphylococcus aureus. FEMS Microbiology/Immunology. 1649:1-9.
Jacob M. Rothfork. Sophie Dessus-Babus, Willem Van Wamel, Ambrose L. Cheung & Hattie D. Gresham. 2003. Fibrinogen Depletion Attenuates Staphylococcus aureus Infection by Preventing Density-Dependent Virulence Gene Up-Regulation. J. Immunol. 171:5389-5395.
K. A. Schmidt, A.C. Manna and A.L. Cheung. 2003. SarT influences sarS expression in Staphylococcus aureus. Infect. Immun. 71:5139-5148.
Li, R., A.C. Manna, A.L. Cheung, and G. Zhang. 2003. The crystal structure of the SarS protein from Staphylococcus aureus. J. Bacteriol. 185:4219-4225.
Ingavale, S.S., W. Van Wamel, and A.L. Cheung. 2003. Characterization of Rat, an important autolysis regulator in Staphylococcus aureus. Mol. Microbiol. 48:1451-1466.
Kupferwasser, I. L., M.R. Yeaman, C. C. Nast, D. Kupferwasser, A. L. Cheung, A. S. Bayer. 2003. Salicylic Acid Attenuates Virulence in Endovascular Infections by Targeting Global Regulatory Pathways in Staphylococcus aureus. J. Clin. Invest. 110:222-233.
Manna, A.C. and A.L. Cheung. sarU, a gene repressible by sarT, is an activator of RNAIII in S. aureus. Infect. Immun. 2003. Infect. Immun. 71:343-353.
Cheung, A.L., S.J. Projan, and H. Gresham. 2002. The genomic aspect of virulence, sepsis and resistance to killing mechanisms in S. aureus. Curr. Infect. Dis. Reports. 4:400-410.
Y.-Q. Xiong, W. Van Wamel, C.C. Nast, M.R. Yeaman, A.L. Cheung and A.S. Bayer. 2002. Activation and transcriptional interaction between two S. aureus agr RNA molecules in an experimental endocarditis model. J. Infect. Dis. 186:668-77.
W. Van Wamel, Y.-Q. Xiong, M.R. Yeaman, C.C. Nast, A.S. Bayer and A.L. Cheung. 2002. Regulation of cap5 promoter activity agr and sarA in vitro and in vivo. Microb. Pathog. 33:73-79.
Cheung, A.L. and Zhang, G. 2002. Global regulation of virulence determinants in S. aureus by the SarA protein family. Front. Sci. 7:d1825-1842.
G. Heyer, A. Pitt, S. Saba, D. Barnes, A. Weber, W. Rush, S. Nguyen, R. Bryan, A. Cheung and A. Prince. 2002. Role of agr and sar dependent gene products in the pathogenesis of Staphylococcus aureus pulmonary infection. Infect. Immun. 70:127-133.
B.Y. Bateman, N. Donegan, T. Jarry, M. Palma and A.L. Cheung. 2001. Evaluation of a tetracycline-inducible promoter in Staphylococcus aureus in vitro and in vivo, and its application in demonstrating the role of sigB in microcolony formation. Infect. Immun. 69:7851-7857
M. Palma, and A. L. Cheung. 2001. ςB activity in Staphylococcus aureus is controlled by RsbU and additional factor(s) during growth. Infect. Immun. 69:7858-7865.
A. L. Cheung, and Gongyi Zhang. 2001. Are the structures of SarA and SarR similar? Trends in Microbiology. 9:570-573.
B. Shenkman, E. Rubenstein, A. L. Cheung, G.E. Brill, R. Darkik, I. Tamarin, N. Savion and D. Varon. 2001. Adherence properties of Staphylococcus aureus under static and flow conditions: role of agr and sar loci, platelets and plasma ligands. Infect. Immun. 69:4473-4478.
T. Kielian, A. Cheung, and W.F. Hickey. 2001. Diminished virulence of an alpha toxin mutant of Staphylococcus aureus in experimental brain abscesses. Infect. Immun. 69:6902-6911.
K. A. Schmidt, A. Manna, S. Gill, and A.L. Cheung. 2001. SarT: a repressor of α-hemolysin synthesis in S. aureus. Infect. Immun. 69:4749-4758.
A. Ratner, R Bryan, B. Nguyen, D. Barnes, A. Weber, A. Pitt, S. Gelber, A. Cheung, A. Prince. 2001. Cystic fibrosis pathogens activate epithelial cells through Ca 2+-dependent MAPK signaling pathways. J.Biol. Chem. 276:19267-19275
I. Siboo, A. L. Cheung, A.S. Bayer and P. Sullam. 2001. Clumping factor mediates binding of Staphylococcus aureus to human platelets. Infect. Immun. 69:3120-3127.
Y. Liu, A. Manna, R. Li, R. C. Murphy, A. L. Cheung and G. Zhang. 2001. Crystal structure of the SarR protein from Staphylococcus aureus. PNAS. 98:6877-6882.
A. L. Cheung, K. Schmidt, B. Bateman, and A. C. Manna. 2001. SarS, a SarA homolog repressible by agr, is an activator of protein A synthesis in Staphylococcus aureus. Infect. Immun. 69:2448-2455.
A.C. Manna, and A.L. Cheung. 2001. Characterization of sarR, a modulator of sar expression in Staphylococcus aureus. Infect. Immun. 69:885-896.
Kahl, B.C., M. Goulian, W. Van Wamel, M. Herrmann, S. Simon, G. Kaplan, G. Peters, and A.L. Cheung. 2000. Staphylococcus aureus RN6390 replicates and induces apoptosis in a pulmonary epithelial cell line derived from a cystic fibrosis patient. Infect. Immun. 68:5385-5392.
Gresham, H. D., J. H. Lawrence, T. E. Caver, Bridget S. Wilson, A. L. Cheung, and F.P. Lindberg. 2000. Survival of Staphylococcus aureus inside neutrophils contributes to infection. J. Immunol. 164:3713-3722.
Wolz, C., A. Steinhuber, P. Pöhlmann-Dietze, Y. T. Chien, A.C. Mann, W. Van Wamel and A.L. Cheung. 2000. Agr-independent regulation of fibronectin binding proteins by the regulatory locus sar in Staphylococcus aureus. Mol. Microbiol. 36:230-243.
Y.T. Chien, A.C. Manna, S.J. Projan, and A.L. Cheung. 1999. SarA, a global regulator of virulence determinants in Staphylococcus aureus, binds to a conserved motif essential for sar-dependent gene regulation. J. Biol.Chem. 274:37169-37176.
Cheung, A. L., Y.-T. Chien and A. S. Bayer. 1999. Hyperproduction of alpha hemolysin in a sigB mutant is associated with elevated SarA expression in Staphylococcus aureus. Infect. Immun. 67:1331-1337.
Cheung, A. L., C. C. Nast, and A. S. Bayer. 1998. Selective activation of sar promoters of S. aureus in the rabbit endocarditis model using Green Fluorescent Protein (gfpuv) transcription fusion as a detection system. Infect. Immun. 66:5988-5993.
Chien, Y. T., and A. L. Cheung. 1998. SarA level is a determinant of agr activation in Staphylococcus aureus. Mol. Microbiol. 31:991-1011.
Fluckiger, U., and A. L. Cheung. 1998. Charcterization of a sar homolog of S. epidermidis. Infect. Immun. 66:2871-2878.
Gillaspy, A.F., C.Y. Lee, S. Sau, A. L. Cheung, and M. S. Smeltzer. 1998. Factors affecting the collagen binding capacity of Staphylococcus aureus. Infect. Immun. 66:3170-3178.
Manna, A., M. G. Bayer, and A. L. Cheung. 1998. Transcriptional analysis of different sar promoters in Staphylococcus aureus. J. Bacteriol. 180:3828-3836.
Chien Y. T., and A. L. Cheung. 1998. Molecular interactions between two global regulators, sar and agr in Staphylococcus aureus. J. Biol. Chem. 273:2645-2652
Bayer, A. S., M. D. Ramos, B. Menzies, M. R. Yeamn, A. Shen and A. L. Cheung. 1997. Hyperproduction of alpha-toxin by Staphylococcus aureus results in paradoxically reduced virulence in experimental endocarditis: a host-defense role for platelet microbicidal proteins. Infect. Immun. 65:4652-4660.
Giraudo, A.T., A. L. Cheung and R. Nagel. 1997. The sae locus of Staphylococcus aureus controls exoprotein synthesis at the transcriptional level. Arch. Microbiol. 168:53-58.
Dhawan, V., M. R. Yeaman, A. L. Cheung, E. Kim, P. A. Sullam, and A. S. Bayer. 1997. Phenotypic resistance to thrombin-induced platelet microbicidal protein in vitro is correlated with enhanced virulence in experimental endocarditis due to Staphylococcus aureus. Infect. Immun. 65:3293-3299.
Cheung, A.L., M. G. Bayer, and J. H. Heinrichs. 1997. The genetic requirement of sar in the expression of RNAII and RNAIII in Staphylococcus aureus. J. Bacteriol. 197:3963-3971.
Cheung, A.L., K. Eberhardt, and J. H. Heinrichs. 1997. Regulation of protein A by the sar and agr loci of Staphylococcus aureus. Infect. Immun. 65:2243-2249.
Liu, S., S. Sela, G. Cohen, J. Jadoun, A. L. Cheung, and I. Ofek. 1997. Genetic evidence for co-regulation of Streptolysin S production and riboflavin biosynthesis in S. pyogenes. Microbiol. Pathog. 22:227-234.
Booth, M.C., A. L. Cheung, H. Hatter, and M. S. Gilmore. 1997. Sar contributes to Staphylococcus aureus virulence in endophthalmitis only in conjunction with agr. Infect. Immun. 65:1550-1556.
Nilsson,I., T. Bremell, C. Rydén, A. L. Cheung, and A. Tarkowski. 1996. The role of staphylococcal accessory regulator (sar) in septic arthritis. Infect. Immun. 64:4438-4443.
Sullam, P.S., A. S. Bayer, W. M. Foss, and A. L. Cheung. 1996. Diminished platelet binding in vitro by S. aureus is associated with reduced virulence in a rabbit model of infective endocarditis. Infect. Immun. 64:4915-4921.
Wolz, C., D. McDevitt, T. J. Foster, and A. L. Cheung. 1996. The influence of agr on fibrinogen binding in S. arueus Newman. Infect. Immun. 64:3142-3147.
Bayer, M. G., J. H. Heinrichs, and A. L. Cheung. 1996. Molecular architecture of the sar locus. J. Bacteriol. 178:4563-4570.
Heinrich, J. H., M. G. Bayer, and A.L. Cheung. 1996. Characterization of the sar locus and its interaction with agr in S. aureus. J. Bacteriol. 178:418-423.
Bayer, A. S., P. M. Sullam, M. Ramos, C. Li, A. L. Cheung, and M. R. Yeaman. 1995. Staphylococcus aureus induces platelet aggregation via a fibrinogen-dependent mechanism which is independent of principal platelet GP IIb/IIIa fibrinogen-binding domains. Infect. Immun. 63:3634-3641.
Dana, R.C., M. Saghbini, D. Lippman, and A. L. Cheung. 1995. Isolating RNA using the new FastPrep system. J. NIH Res. 7:61.
Cheung, A.L., S. J. Projan, R. Edelstein, and V. A. Fischetti. 1995. Cloning, expression and nucleotide sequencing of a S. aureus gene (fbpA) encoding a fibrinogen binding protein. Infect. Immun. 63:1914-1920.
Cheung, A. L., C. Wolz, M. R. Yeaman, A. S. Bayer. 1995. Insertional inactivation of a chromosomal locus that modulates expression of potential virulence determinants in Staphylococcus aureus. J. Bacteriol. 177:3220-3226.
Lo, S. K., A. L. Cheung, Q. Zheng, and R. L. Silverstein. 1995. Induction of tissue factor on monocytes by adhesion to endothelial cells. J. Immunol. 154:4768-4777.
Cheung, A. L., K. Eberhardt and V. A. Fischetti. 1994. A method to isolate RNA from gram-positive bacteria and mycobacteria. Anal. Biochem. 222:511-514.
Cheung, A.L., K. Eberhardt, E. Chung, M. Yeaman, P. Sullam, M. Ramos, and A. S. Bayer. 1994. Diminished virulence of a sar-/agr- mutant of Staphylococcus aureus in the rabbit model of endocarditis. J. Clin. Invest. 94:1815-1822.
Ren, K., J. D. Bannan, V. Pancholi, A. L. Cheung, J. C. Robbins, V. A. Fischetti, and J. B. Zabriskie. 1994. Purification, characterization and biological properties of a new toxin from S. aureus inducing TSS-like illness in rabbits - J. Exp. Med. 180:1675-1683.
Cheung, A.L. and S. J. Projan. 1994. Cloning and sequencing of sarA: a gene required for the expression of agr. J. Bacteriol. 176:4168-4172.
Cheung, A.L. and P. Ying. 1994. Regulation of α and β hemolysins by the sar locus of S. aureus. J. Bacteriol. 176:580-585.
Cheung, A.L., M. Yeaman, and A. S. Bayer. 1994. The role of the sar locus in the induction of experimental endocarditis in rabbits. Infect. Immun. 62:1719-1725.
Cheung, A.L., J. M. Koomey, C. A. Butler, S. J. Projan, and V. A. Fischetti. 1992. Regulation of exoprotein expression in Staphylococcus aureus by a locus (sar) distinct from agr. Proc. Natl. Acad. Sci. USA. 89:6462-6466.
Cheung, A.L., J. M. Koomey, S. Lee, E. A. Jaffe, and V. A. Fischetti. 1991. Recombinant human tumor necrosis factor alpha promotes adherence of Staphylococcus aureus to endothelial cells. Infect. Immun. 59:3827-3831.
Cheung, A.L., M. Krishnan, E. A. Jaffe, and V. A. Fischetti. 1991. Fibrinogen acts as a bridging molecule in the adherence of Staphylococcus aureus to cultured human endothelial cells. J. Clin. Invest. 87:2236-2245.
Cheung, A.L. and V. A. Fischetti. 1991. The role of fibrinogen in mediating staphylococcal adherence to fibers. J. Surg. Res. 50:150-155.
Cheung, A.L., P. Ying, and V. A. Fischetti. 1991. A method to detect proteinase activity using unprocessed X-ray films. Anal. Biochem. 193:20-23.
Cheung, A.L. and V. A. Fischetti. 1990. The role of fibrinogen in staphylococcal adherence to catheters in vitro. J. Infect. Dis. 161:1177-1186.
Cheung, A.L. and V. A. Fischetti. 1989. The role of surface proteins in staphylococcal adherence to fibers in vitro. J. Clin. Invest. 83:2041-2049.
Greenberg, D.P., A. S. Bayer, A. L. Cheung, and J. I. Ward. 1989. Protective efficacy of protein A-specific antibody against bacteremic infection due to Staphylococcus aureus in an infant rat model. Infect. Immun. 57:1113-1118.
Cheung, A.L., A. S. Bayer, J. Peter, and J. I. Ward. 1988. Surface proteins of Staphylococcus aureus. Rev. Infect. Dis. 10 Suppl.2:S351-S355.
Cheung, A.L. and V. A. Fischetti. 1988. Variation in the expression of cell wall proteins of Staphylococcus aureus grown on solid and liquid media. Infect. Immun. 56:1061-1065.
Cheung, A.L., A. S. Bayer, J. Peters, and J. I. Ward. 1987. Analysis by gel electrophoresis, western blot and peptide mapping of protein A heterogeneity in Staphylococcus aureus strains. Infect. Immun. 55:843-847.