J Biomed Opt. 2010 Sep-Oct;15(5):051602. doi: 10.1117/1.3483902. ABSTRACT Fluorescence molecular tomography (FMT) systems coupled to conventional imaging modalities such as magnetic resonance imaging (MRI) and computed tomography provide unique opportunities to combine data sets and improve image quality and content. Yet, the ideal approach to combine these complementary data is still not obvious. This preclinical…Continue Reading Comparing implementations of magnetic-resonance-guided fluorescence molecular tomography for diagnostic classification of brain tumors
Imaging targeted-agent binding in vivo with two probes
J Biomed Opt. 2010 May-Jun;15(3):030513. doi: 10.1117/1.3449109. ABSTRACT An approach to quantitatively image targeted-agent binding rate in vivo is demonstrated with dual-probe injection of both targeted and nontargeted fluorescent dyes. Images of a binding rate constant are created that reveal lower than expected uptake of epidermal growth factor in an orthotopic xenograft pancreas tumor (2.3…Continue Reading Imaging targeted-agent binding in vivo with two probes
Fluorescent molecular imaging and dosimetry tools in photodynamic therapy
Methods Mol Biol. 2010;635:207-22. doi: 10.1007/978-1-60761-697-9_15. ABSTRACT Measurement of fluorescence and phosphorescence in vivo is readily used to quantify the concentration of specific species that are relevant to photodynamic therapy. However, the tools to make the data quantitatively accurate vary considerably between different applications. Sampling of the signal can be done with point samples, such…Continue Reading Fluorescent molecular imaging and dosimetry tools in photodynamic therapy
Imaging and photodynamic therapy: mechanisms, monitoring, and optimization
Chem Rev. 2010 May 12;110(5):2795-838. doi: 10.1021/cr900300p. NO ABSTRACT PMID:20353192 | PMC:PMC2896821 | DOI:10.1021/cr900300p…Continue Reading Imaging and photodynamic therapy: mechanisms, monitoring, and optimization
MRI-coupled fluorescence tomography quantifies EGFR activity in brain tumors
Acad Radiol. 2010 Mar;17(3):271-6. doi: 10.1016/j.acra.2009.11.001. ABSTRACT RATIONALE AND OBJECTIVES: This report demonstrates the diagnostic potential of magnetic resonance imaging (MRI)-coupled fluorescence molecular tomography (FMT) to determine epidermal growth factor receptor (EGFR) status in brain cancer. MATERIALS AND METHODS: Two orthotopic glioma xenograft models were used in this study: one represented high EGFR expression and…Continue Reading MRI-coupled fluorescence tomography quantifies EGFR activity in brain tumors