Month: August 2012

Computed tomography-guided time-domain diffuse fluorescence tomography in small animals for localization of cancer biomarkers

J Vis Exp. 2012 Jul 17;(65):e4050. doi: 10.3791/4050. ABSTRACT Small animal fluorescence molecular imaging (FMI) can be a powerful tool for preclinical drug discovery and development studies. However, light absorption by tissue chromophores (e.g., hemoglobin, water, lipids, melanin) typically limits optical signal propagation through thicknesses larger than a few millimeters. Compared to other visible wavelengths,…Continue Reading Computed tomography-guided time-domain diffuse fluorescence tomography in small animals for localization of cancer biomarkers