Phys Med Biol. 2014 May 21;59(10):2341-51. doi: 10.1088/0031-9155/59/10/2341. Epub 2014 Apr 17. ABSTRACT Dual-tracer molecular imaging is a powerful approach to quantify receptor expression in a wide range of tissues by using an untargeted tracer to account for any nonspecific uptake of a molecular-targeted tracer. This approach has previously required the pharmacokinetics of the receptor-targeted…Continue Reading Accounting for pharmacokinetic differences in dual-tracer receptor density imaging
Modulation of hypoxia by magnetic nanoparticle hyperthermia to augment therapeutic index
Adv Exp Med Biol. 2014;812:87-95. doi: 10.1007/978-1-4939-0620-8_12. ABSTRACT A hypoxic microenvironment in solid tumors has been known to cause resistance to standard therapies and to increase the malignant potential of tumors. The utilization of magnetic nanoparticle hyperthermia (mNPH) has shown promise in improving therapeutic outcome by (1) killing of hypoxic tumor cells directly and (2)…Continue Reading Modulation of hypoxia by magnetic nanoparticle hyperthermia to augment therapeutic index