Nat Med. 2014 Nov;20(11):1348-53. doi: 10.1038/nm.3732. Epub 2014 Oct 26. ABSTRACT Lymph node biopsy is employed in many cancer surgeries to identify metastatic disease and to determine cancer stage, yet morbidity and diagnostic delays associated with lymph node biopsy could be avoided if noninvasive imaging of nodal involvement were reliable. Molecular imaging has potential in…Continue Reading Microscopic lymph node tumor burden quantified by macroscopic dual-tracer molecular imaging
Quantitative in vivo immunohistochemistry of epidermal growth factor receptor using a receptor concentration imaging approach
Cancer Res. 2014 Dec 15;74(24):7465-74. doi: 10.1158/0008-5472.CAN-14-0141. Epub 2014 Oct 24. ABSTRACT As receptor-targeted therapeutics become increasingly used in clinical oncology, the ability to quantify protein expression and pharmacokinetics in vivo is imperative to ensure successful individualized treatment plans. Current standards for receptor analysis are performed on extracted tissues. These measurements are static and often…Continue Reading Quantitative in vivo immunohistochemistry of epidermal growth factor receptor using a receptor concentration imaging approach
Oxygen microenvironment affects the uptake of nanoparticles in head and neck tumor cells
Proc SPIE Int Soc Opt Eng. 2013 Feb 26;8584:85840F. doi: 10.1117/12.2008067. ABSTRACT Survival of head and neck cancer patients has not improved in several decades despite advances in diagnostic and therapeutic techniques. Tumor hypoxia in head and neck cancers is a critical factor that leads to poor prognosis, resistance to radiation and chemotherapies, and increased…Continue Reading Oxygen microenvironment affects the uptake of nanoparticles in head and neck tumor cells