J Biomed Opt. 2017 Dec;22(12):1-12. doi: 10.1117/1.JBO.22.12.121613. ABSTRACT Wide local excision (WLE) of tumors with negative margins remains a challenge because surgeons cannot directly visualize the mass. Fluorescence-guided surgery (FGS) may improve surgical accuracy; however, conventional methods with direct surface tumor visualization are not immediately applicable, and properties of tissues surrounding the cancer must be…Continue Reading Development and evaluation of a connective tissue phantom model for subsurface visualization of cancers requiring wide local excision
Assessing daylight & low-dose rate photodynamic therapy efficacy, using biomarkers of photophysical, biochemical and biological damage metrics in situ
Photodiagnosis Photodyn Ther. 2017 Dec;20:227-233. doi: 10.1016/j.pdpdt.2017.10.005. Epub 2017 Oct 14. ABSTRACT BACKGROUND: Sunlight can activate photodynamic therapy (PDT), and this is a proven strategy to reduce pain caused byconventional PDT treatment, but assessment of this and other alternative low dose rate light sources, and their efficacy, has not been studied in an objective, controlled…Continue Reading Assessing daylight & low-dose rate photodynamic therapy efficacy, using biomarkers of photophysical, biochemical and biological damage metrics in situ