Chengyue Li, Veronica C. Torres, Yusheng He, Xiaochun Xu, Yusairah Basheer, Georgia Papavasiliou, Kimberley S. Samkoe, Jovan G. Brankov & Kenneth M. Tichauer Mol Imaging Biol. 2021 Aug;23(4):537-549. doi: 10.1007/s11307-021-01587-z. Epub 2021 Feb 16. ABSTRACT PURPOSE: Correctly identifying nodal status is recognized as a critical prognostic factor in many cancer types and is essential to guide adjuvant treatment. Currently, surgical removal of lymph nodes…Continue Reading Intraoperative Detection of Micrometastases in Whole Excised Lymph Nodes Using Fluorescent Paired-Agent Imaging Principles: Identification of a Suitable Staining and Rinsing Protocol
Task-based evaluation of fluorescent-guided cancer surgery as a means of identifying optimal imaging agent properties in the context of variability in tumor- and healthy-tissue physiology
Kenneth M. Tichauer, Cheng Wang, Xiaochun Xu, Kimberley S. Samkoe Proc SPIE Int Soc Opt Eng. 2020 Feb;11222:112220O. doi: 10.1117/12.2546700. Epub 2020 Feb 19. ABSTRACT Fluorescent molecular-guided surgery (FGS) is at a tipping point in terms of clinical approval and adoption in a number cancer applications, with ongoing phase 0 and phase 1 clinical trials being carried out…Continue Reading Task-based evaluation of fluorescent-guided cancer surgery as a means of identifying optimal imaging agent properties in the context of variability in tumor- and healthy-tissue physiology
Hyperspectral imaging and spectral unmixing for improving whole-body fluorescence cryo-imaging
Dennis Wirth, Brook Byrd, Boyu Meng, Rendall R. Strawbridge, Kimberley S. Samkoe, and Scott C. Davis Biomed Opt Express. 2020 Dec 16;12(1):395-408. doi: 10.1364/BOE.410810. eCollection 2021 Jan 1. ABSTRACT Whole-animal fluorescence cryo-imaging is an established technique that enables visualization of the biodistribution of labeled drugs, contrast agents, functional reporters and cells in detail. However, many…Continue Reading Hyperspectral imaging and spectral unmixing for improving whole-body fluorescence cryo-imaging