Elif Kayaalp-Nalbant, Cody Rounds, Negar Sadeghipour, Boyu Meng, Margaret R. Folaron, Chandrika Haldar, Rendall R. Strawbridge, Kimberley S. Samkoe, Scott C. Davis, Kenneth M. Tichauer Proc SPIE Int Soc Opt Eng. 2020 Feb;11219:112190G. doi: 10.1117/12.2545182. Epub 2020 Feb 19. ABSTRACT A paired-agent fluorescent molecular imaging strategy is presented as a method to measure drug target engagement in whole tumor imaging. The protocol involves dynamic…Continue Reading A paired-agent fluorescent molecular imaging strategy for quantifying antibody drug target engagement in in vivo window chamber xenograft models
Effect of nonspecific binding of imaging agents to plasma protein in the paired-agent imaging for resection during surgery (PAIRS)
Xiaochun Xu 1, Kenneth M Tichauer 2, Kimberley S Samkoe 3 Proc SPIE Int Soc Opt Eng. 2020 Feb;11219:112190P. Epub 2020 Feb 19. ABSTRACT Long-term survival of head and neck squamous cell carcinoma (HNSCC) patients have proven to be correlated with negative surgical margins. Paired-Agent Imaging for Resection during Surgery (PAIRS) is capable of drawing the fine line between tumor…Continue Reading Effect of nonspecific binding of imaging agents to plasma protein in the paired-agent imaging for resection during surgery (PAIRS)