Hira S. Sardar MS, Qais Zai MS, Xiaochun Xu PhD, Jason R. Gunn BS, Brian W. Pogue PhD, Keith D. Paulsen PhD, Eric R. Henderson MD, Kimberley S. Samkoe PhD J Surg Oncol. 2020 Dec;122(8):1711-1720. doi: 10.1002/jso.26190. Epub 2020 Sep 3. ABSTRACT BACKGROUND: Current practices for fluorescence-guided cancer surgery utilize a single fluorescent agent, but homogeneous distribution throughout the tumor is difficult…Continue Reading Dual-agent fluorescent labeling of soft-tissue sarcomas improves the contrast based upon targeting both interstitial and cellular components of the tumor milieu
Quantification of Osteosarcoma Mineralization on Plain Radiographs – Novel Software Applications to Assess Response to Chemotherapy
Xiaochun Xu, Kimberley S. Samkoe, Megan E. Anderson, Eric R. Henderson Proc SPIE Int Soc Opt Eng. 2020 Feb;11224:112240K. doi: 10.1117/12.2546954. Epub 2020 Feb 25. ABSTRACT Osteosarcoma is the most common primary malignant bone tumor in children. Patient survival with osteosarcoma is heavily influenced by the response to chemotherapy, measured by tumor necrosis upon histological analysis. Unfortunately, response…Continue Reading Quantification of Osteosarcoma Mineralization on Plain Radiographs – Novel Software Applications to Assess Response to Chemotherapy
Effect of preoperative cancer treatment on epidermal growth factor receptor (EGFR) receptor expression level in ABY-029 guided sarcoma surgery
Xiaochun Xu, Kimberley S. Samkoe, Eric R. Henderson Proc SPIE Int Soc Opt Eng. 2020 Feb;11222:112220Y. doi: 10.1117/12.2546963. Epub 2020 Feb 19. ABSTRACT Surgical excision via wide local excision (WLE) of the primary sarcoma tumor is a mainstay of treatment due to the limited effectiveness of chemotherapy and radiation. Even with attempts at WLE, 22-34% of the…Continue Reading Effect of preoperative cancer treatment on epidermal growth factor receptor (EGFR) receptor expression level in ABY-029 guided sarcoma surgery
Simultaneous extracellular and intracellular quantification of EGFR using paired-agent imaging in an <em>in ovo</em> tumor model
Kimberley S. Samkoe, Emily Schultz, Allison Solanki, Lei Wang, Jesse Korber, Kenneth M. Tichauer, Summer L. Gibbs Proc SPIE Int Soc Opt Eng. 2019 Feb;10859:108590F. doi: 10.1117/12.2510778. Epub 2019 Feb 28. ABSTRACT Quantification of protein concentrations is often a static and tissue destructive technique. Paired-agent imaging (PAI) using matched targeted and untargeted agents has been established as a dynamic method for…Continue Reading Simultaneous extracellular and intracellular quantification of EGFR using paired-agent imaging in an <em>in ovo</em> tumor model
Intracellular paired agent imaging enables improved evaluation of tyrosine kinase inhibitor target engagement
Allison Solanki,1 Lei Wang,1 Jesse Korber,1 Nathan McMahon,1 Kenneth Tichauer,4 Kimberley S. Samkoe,5 and Summer L. Gibbs1,2,3,* Proc SPIE Int Soc Opt Eng. 2020 Feb;11219:112190F. Epub 2020 Feb 19. ABSTRACT Targeting the aberrant epidermal growth factor receptor (EGFR) signaling pathway is an attractive choice for many cancers (e.g., non-small cell lung carcinoma (NSCLC) and head and neck squamous cell carcinoma (HNSCC)). Despite…Continue Reading Intracellular paired agent imaging enables improved evaluation of tyrosine kinase inhibitor target engagement
Topical dual-probe staining using quantum dot-labeled antibodies for identifying tumor biomarkers in fresh specimens
Boyu Meng, Margaret R. Folaron, Brook K. Byrd, Kimberley S. Samkoe, Rendall S. Strawbridge, Connor Barth, Summer L. Gibbs, Scott C. Davis PLoS One. 2020 Mar 11;15(3):e0230267. doi: 10.1371/journal.pone.0230267. eCollection 2020. ABSTRACT PURPOSE: Rapid, intra-operative identification of tumor tissue in the margins of excised specimens has become an important focus in the pursuit of reducing…Continue Reading Topical dual-probe staining using quantum dot-labeled antibodies for identifying tumor biomarkers in fresh specimens
Noninvasive imaging of dual-agent uptake in glioma and normal tissue using MRI-coupled fluorescence tomography
Boyu Meng, Margaret R. Folaron, Rendall R. Strawbridge, Negar Sadeghipour, Kimberley S. Samkoe, Kenneth Tichauer, Scott C. Davis Proc SPIE Int Soc Opt Eng. 2019 Feb;10874:1087413. doi: 10.1117/12.2510515. Epub 2019 Mar 1. ABSTRACT As the role of immuno-oncological therapeutics expands, the capacity to noninvasively quantify molecular targets and drug-target engagement is increasingly critical to drug development efforts and treatment monitoring. Previously,…Continue Reading Noninvasive imaging of dual-agent uptake in glioma and normal tissue using MRI-coupled fluorescence tomography
Effect of staining temperature on topical dual stain imaging of tissue specimens for tumor identification
Margaret R. Folaron, Rendall R. Strawbridge, Kimberley S. Samkoe, Summer L. Gibbs, Scott C. Davis Proc SPIE Int Soc Opt Eng. 2019 Feb;10862:108620L. doi: 10.1117/12.2509848. Epub 2019 Mar 7. ABSTRACT In the pursuit of reducing re-excision rates in breast conserving surgery, a dual probe specimen staining technique has emerged as a promising approach to identify positive margins during surgery….Continue Reading Effect of staining temperature on topical dual stain imaging of tissue specimens for tumor identification
On the use of fluorescein-based contrast agents as analogs to MRI-gadolinium agents for imaging brain tumors
Scott C. Davis, Margaret R. Folaron, Rendall R. Strawbridge, Caroline E. Filan, Kimberley S. Samkoe, David W. Roberts Proc SPIE Int Soc Opt Eng. 2019 Feb;10862:108620V. doi: 10.1117/12.2510905. Epub 2019 Mar 7. ABSTRACT Magnetic resonance imaging (MRI) of gadolinium (Gd)-based contrast agents plays a central role in managing the treatment of intracranial tumors. These images are involved in diagnosis, surgical…Continue Reading On the use of fluorescein-based contrast agents as analogs to MRI-gadolinium agents for imaging brain tumors
High-Resolution Ex Vivo Elastography to Characterize Tumor Stromal Heterogeneity In Situ in Pancreatic Adenocarcinoma
Phuong Vincent; Hexuan Wang; Michael Nieskoski; Jason R. Gunn; Kalya Marra; P. Jack Hoopes; Kimberley S. Samkoe IEEE Trans Biomed Eng. 2020 Sep;67(9):2490-2496. doi: 10.1109/TBME.2019.2963562. Epub 2020 Jan 1. ABSTRACT OBJECTIVE: Tumor stiffening in pancreatic adenocarcinoma (PDAC) has been linked to cancer progression and lack of therapy response, yet current elastography tools cannot map stiffness in a whole tumor field-of-view with…Continue Reading High-Resolution Ex Vivo Elastography to Characterize Tumor Stromal Heterogeneity In Situ in Pancreatic Adenocarcinoma