Category: Publications

Kimberley S. Samkoe, Yeonjae Park, Kayla Marra, Eunice Y. Chen, Kenneth M. Tichauer Proc SPIE Int Soc Opt Eng. 2019 Feb;10853:108530P. doi: 10.1117/12.2510897. Epub 2019 Feb 26. ABSTRACT Head and neck cancers overwhelmingly overexpress epidermal growth factor receptor (EGFR). This overexpression has been utilized for head and neck cancers using molecular targeted agents for therapy and cancer cell detection….Continue Reading Paired-agent imaging for detection of head and neck cancers

Proc SPIE Int Soc Opt Eng. 2019 Feb;10862:1086212. doi: 10.1117/12.2510935. Epub 2019 May 22. ABSTRACT Microdose administration of ABY-029, an anti-epidermal growth factor receptor Affibody molecule conjugated to IRDye 800CW, is being studied in a Phase 0 trial for resection of soft-tissue sarcomas. The excised tissue of a single patient in the microdose administration group…Continue Reading Measuring microdose ABY-029 fluorescence signal in a primary human soft-tissue sarcoma resection

Kimberley S. Samkoe PhD, Hira S. Sardar, Brent D. Bates, Niki N. Tselepidakis, Jason R. Gunn, Kevin A. Hoffer-Hawlik, Joachim Feldwisch PhD, Brian W. Pogue PhD, Keith D. Paulsen PhD, Eric R. Henderson MD J Surg Oncol. 2019 Jun;119(8):1077-1086. doi: 10.1002/jso.25468. Epub 2019 Apr 4. ABSTRACT BACKGROUND AND OBJECTIVES: Fluorescence-guided surgery using epidermal growth factor receptor (EGFR) targeting has been performed successfully in clinical…Continue Reading Preclinical imaging of epidermal growth factor receptor with ABY-029 in soft-tissue sarcoma for fluorescence-guided surgery and tumor detection

Margaret Folaron PhD1, Rendall Strawbridge BS1, Kimberley S. Samkoe PhD1,2,3, Caroline Filan1, David W. Roberts MD2,4, andScott C. Davis PhD1,5 J Neurosurg. 2018 Sep 7;131(3):724-734. doi: 10.3171/2018.4.JNS172644. ABSTRACT OBJECTIVE: The use of the optical contrast agent sodium fluorescein (NaFl) to guide resection of gliomas has been under investigation for decades. Although this imaging strategy assumes the agent remains confined to the vasculature except in…Continue Reading Elucidating the kinetics of sodium fluorescein for fluorescence-guided surgery of glioma

Photochem Photobiol. 2018 Nov;94(6):1167-1171. doi: 10.1111/php.13003. Epub 2018 Sep 28. ABSTRACT Since many types of cancers overexpress EGFR, this surface receptor has been used as a target for therapy or diagnosis of malignant disease. Uptake kinetics of EGFR-targeted fluorescent Affibody (ABY-029) were studied with a view toward optimizing efficacy of tumor detection in a glioma…Continue Reading Optimizing Glioma Detection Using an EGFR-Targeted Fluorescent Affibody

Kimberley S. Samkoe, PhD, Brent D. Bates, MS, Jonathan T. Elliott, PhD, Ethan LaRochelle, BE, Jason R. Gunn, BS, Kayla Marra, BS, Joachim Feldwisch, PhD, Dipak B. Ramkumar, MD, MS, David F. Bauer, MD, Keith D. Paulsen, PhD, Brian W. Pogue, PhD, Eric R. Henderson, MD Cancer Control. 2018 Jan-Mar;25(1):1073274817752332. doi: 10.1177/1073274817752332. ABSTRACT The excision of tumors by wide local excision is challenging because the mass must be removed entirely without ever viewing it directly. Positive margin…Continue Reading Application of Fluorescence-Guided Surgery to Subsurface Cancers Requiring Wide Local Excision: Literature Review and Novel Developments Toward Indirect Visualization

J Biomed Opt. 2017 Dec;22(12):1-12. doi: 10.1117/1.JBO.22.12.121613. ABSTRACT Wide local excision (WLE) of tumors with negative margins remains a challenge because surgeons cannot directly visualize the mass. Fluorescence-guided surgery (FGS) may improve surgical accuracy; however, conventional methods with direct surface tumor visualization are not immediately applicable, and properties of tissues surrounding the cancer must be…Continue Reading Development and evaluation of a connective tissue phantom model for subsurface visualization of cancers requiring wide local excision

Photodiagnosis Photodyn Ther. 2017 Dec;20:227-233. doi: 10.1016/j.pdpdt.2017.10.005. Epub 2017 Oct 14. ABSTRACT BACKGROUND: Sunlight can activate photodynamic therapy (PDT), and this is a proven strategy to reduce pain caused byconventional PDT treatment, but assessment of this and other alternative low dose rate light sources, and their efficacy, has not been studied in an objective, controlled…Continue Reading Assessing daylight & low-dose rate photodynamic therapy efficacy, using biomarkers of photophysical, biochemical and biological damage metrics in situ

Mol Imaging Biol. 2017 Aug;19(4):512-521. doi: 10.1007/s11307-016-1033-y. ABSTRACT PURPOSE: ABY-029, a synthetic Affibody peptide, Z03115-Cys, labeled with a near-infrared fluorophore, IRDye® 800CW, targeting epidermal growth factor receptor (EGFR) has been produced under good manufacturing practices for a US Food and Drug Administration-approved first-in-use human study during surgical resection of glioma, as well as other tumors….Continue Reading Toxicity and Pharmacokinetic Profile for Single-Dose Injection of ABY-029: a Fluorescent Anti-EGFR Synthetic Affibody Molecule for Human Use

Clin Cancer Res. 2017 May 1;23(9):2203-2212. doi: 10.1158/1078-0432.CCR-16-1400. Epub 2016 Oct 31. ABSTRACT Purpose: While extent of tumor resection is an important predictor of outcome in glioma, margin delineation remains challenging due to lack of inherent contrast between tumor and normal parenchyma. Fluorescence-guided surgery is promising for its ability to enhance contrast through exogenous fluorophores;…Continue Reading Simultaneous <em>In Vivo</em> Fluorescent Markers for Perfusion, Protoporphyrin Metabolism, and EGFR Expression for Optically Guided Identification of Orthotopic Glioma