Category: Publications

J Biomed Opt. 2009 May-Jun;14(3):034034. doi: 10.1117/1.3155512. ABSTRACT An automated algorithm and methodology is presented to identify tumor-tissue morphologies based on broadband scatter data measured by raster scan imaging of the samples. A quasi-confocal reflectance imaging system was used to directly measure the tissue scatter reflectance in situ, and the spectrum was used to identify…Continue Reading Automated identification of tumor microscopic morphology based on macroscopically measured scatter signatures

J Biomed Opt. 2009 Jan-Feb;14(1):014004. doi: 10.1117/1.3065540. ABSTRACT Highly localized reflectance measurements can be used to directly quantify scatter changes in tissues. We present a microsampling approach that is used to raster scan tumors to extract parameters believed to be related to the tissue ultrastructure. A confocal reflectance imager was developed to examine scatter changes…Continue Reading Quantitative imaging of scattering changes associated with epithelial proliferation, necrosis, and fibrosis in tumors using microsampling reflectance spectroscopy

J Biomed Opt. 2007 May-Jun;12(3):034025. doi: 10.1117/1.2750663. ABSTRACT Complete blood vessel occlusion is required for the treatment of age-related macular degeneration (AMD). AMD is the leading cause of blindness in developed countries and current treatment regimes have potential to cause collateral damage, or do not remove pre-existing unwanted vasculature. It has been proposed that two-photon…Continue Reading Complete blood vessel occlusion in the chick chorioallantoic membrane using two-photon excitation photodynamic therapy: implications for treatment of wet age-related macular degeneration

Photochem Photobiol. 2006 Jan-Feb;82(1):152-7. doi: 10.1562/2005-05-28-RA-549. ABSTRACT Two-photon excitation photodynamic therapy (TPE-PDT) is being developed as an improved treatment for retinal diseases. TPE-PDT has advantages over one-photon PDT, including lower collateral damage to healthy tissue and more precise delivery of PDT. As with one-photon PDT, there can be local photochemical depletion of oxygen during TPE-PDT….Continue Reading Photobleaching kinetics of optically trapped multilamellar vesicles containing verteporfin using two-photon excitation section sign

J Biomed Opt. 2003 Jul;8(3):410-7. doi: 10.1117/1.1577117. ABSTRACT Two-photon excitation photodynamic therapy (TPE-PDT) is being investigated as a clinical treatment for age-related macular degeneration (AMD). TPE-PDT has the potential to provide a more specific and therefore advantageous therapy regime than traditional one-photon excitation PDT. The highly vascularized 8 to 9-day-old chicken chorioallantoic membrane (CAM) is…Continue Reading Application of an ex ovo chicken chorioallantoic membrane model for two-photon excitation photodynamic therapy of age-related macular degeneration