Pain is defined subjectively, but an objective measure of the experience promises to transform its management. Read new article in Nature!
Using functional magnetic resonance imaging, for example, several groups have identified patterns of brain activity that reflect different types of pain — including sensory, emotional and cognitive aspects of the experience. And some researchers have achieved similar results with electrophysiological recordings.
These efforts have yielded some of the most accurate pain-related signatures so far, offering insights into the neural pathways associated with pain and highlighting targets for therapeutic interventions. “This lays the groundwork for identifying potential treatment targets,” says Tor Wager, a neuroscientist at Dartmouth College in Hanover, New Hampshire.