Microbe-Microbe and Microbe-Host Interactions
Jeffrey Hollomon was first author on a paper with Nora Grahl, Sven Willger and Katja Koeppen (Stanton Lab) in mSphere describing the global role of cyclic AMP signaling in pH-dependent responses in Candida albicans. This work provides important insight into how Candida responds to the acidic environments found in single species biofilms, in interactions with the host, and in mixed species communities.
Congratulations to Dr. Jack Hammond, Ph.D. for successfully defending his thesis entitled “Characterization of the Pseudomonas aerguinosa response to hypoxia in biofilmss and infections, as mediated by the oxygen responsive transcription factor, Anr”! Lars Dietrich, Columbia University, was the outside examiner and the day was full of excellent scientific discussions!
In this manuscript by Gifford et al, we analyze Pseudomonas profiles in serial samples from four different
subjects. These data found common trends across subjects and highlight the use of this tool for assessing P. aeruginosa response to treatment.
Check out the new paper by Jack Hammond, a graduate student in the lab . In it, we show that LasR-defective isolates not only evolve in chronic infections, but also cause acute corneal infections. We found
two endemic LasR- strains that were well-distributed geographically in India. This work is published in mSphere.
Kimberely Lewis, Elora Demers, and Georgia Doing attended the MDIBL summer course on Applied Bioinformatics. Had a great time in Maine and learned lots.