Ethan LaRochelle recently attended the World Molecular Imaging Congress (WMIC) in Montreal. His abstract titled “Real-time non-contact in vivo pO2 imaging during radiotherapy of unanesthetized mice,” was selected as one of the best abstracts at the conference. Ethan presented this work during the Highlights in Instrumentation & Methodology session. Thayer faculty Kimberley Samkoe PhD and Jonathan Elliot PhD, and Optics in Medicine collaborator Dr. Eric Henderson, also attended and presented research at the conference.
The Center for Imaging Medicine at Dartmouth is once again hosting our summer Optics Seminars. This year’s speakers are:
- 6/28/2019 – Kavon Karrobi, PhD candidate, Biomedical Engineering, Boston University.
- 7/9/2019 – Michael Durst, PhD, Department of Physics, Middlebury College.
- 7/11/2019 – Kenneth Tichauer, PhD, Biomedical Engineering, Illinois Institute of Technology.
- 7/23/2019 – Irving Bigio, PhD, Biomedical Engineering, Boston University
- 8/6/2019 – Steve Jacques, PhD, Biomedical Engineering, Tufts University
- 8/13/2019 – Mark Niedre, PhD, Bioengineering, Northeastern University
- 8/20/2019 – Jinyang Liang, PhD, Institut National de la Recherche Scientifique, Varennes, Quebec
For more information on seminar locations, please contact Sally Hull.
At this year’s SPIE International Graduate Summer School for Biophotonics, Thayer PhD student Samuel Streeter won the Best Poster Presentation award. His work was titled “High Spatial Frequency Structured Light Imaging Texture Analysis for Rapid and Wide Field-of-View Surface Tissue Characterization.” Congratulations Sam!
This was the 9th International Graduate summer school and was focused on the study of optical methods and instruments that use light to measure interactions with tissue for diagnosis and treatment monitoring. The program is taught by internationally renowned experts in biophotonics, this year including Thayer Professor Brian Pogue.
At the AAPM Spring Clinical Meeting, Thayer School of Engineering PhD Student Muhammad (Ramish) Ashraf took the third place prize in the Young Investigator’s Symposium.
Ramish’s talk was titled “Remote, Real-Time and High-Resolution Optical Imaging of Small Beamlets in Radiotherapy” and it evaluated the use of Radioluminescence as a Quality Assurance (QA) tool for small beamlets in radiotherapy. Optical Imaging can be used to image a variety of dynamic Volumetric Modulated Arc Therapy (VMAT) and Stereotactic RadioSurgery (SRS) plans. The technique is sensitive to MLC and Gantry Angle errors. High spatial resolution renders the technique a viable solution for small field dosimetry.
At the March 15th winter meeting of the New England Chapter of the American Association of Physicists in Medicine (AAPM), Thayer PhD student Daniel Alexander took home 1st prize in the Peter Neurath Young Investigator Symposium (YIS).
The event was held at the Museum of Science in Boston, MA, and provided an opportunity for medical physics students and professional physicists, dosimetrists and therapists to hear the latest news and network. It featured invited speakers, a research panel, and eight YIS presentations. New this year, YIS presentations were made in 3-minute SLAM competition format to engage the audience and inform experts and interested attendees from outside medical physics.
Dan’s talk was titled “Imaging Cherenkov Emission in Head and Neck Radiotherapy,” and detailed the use of Cherenkov imaging to conduct adaptive radiation treatment planning for Head and Neck cancer patients. Cherenkov technology provides the ability to non-invasively images radiation dose delivery. Working with Radiation Oncologist Dr. Lesley Jarvis at Dartmouth-Hitchcock Medical Center, Dan used a custom mask restraint to image human subjects as well as with tissue phantoms.
Dr. Jennifer Shell was awarded grant funding from the Norris Cotton Cancer Center for her proposed project, “Tumor Targeting Vitamin B12 Derivatives for X-Ray Activated Chemotherapy.” One of 12 proposals submitted, this project received $50,000 for one year. Dr. Shell will work with Dr. Brian Pogue, a PDT and radiotherapy expert, Dr. David Gladstone, who has expertise in medical physics, and Dr. Lesley Jarvis, a specialist in clinical radiotherapy.
The project builds off a novel delivery platform the group developed in which a chemotherapy drug is conjugated to an alkylcobalamin scaffold, a derivative of vitamin B12, and both are transported into cells by receptors. Since pancreatic cancer has an abundance of these receptors, the study will focus on pancreatic ductal adenocarcinoma (PDAC). Because systemically delivered chemotherapy agents cause significant side effects, this study uses targets drug delivery to the tumor to minimize the untargeted systemic effects. In addition, the team’s alkylcobalamin scaffold is photo-activatable so that light can be used to activate the compound and release the chemotherapy selectively in the tumor. The approach is called photopharmaceutical therapy (PPT).