A recent study by Rachael Hachadorian and colleagues in Nature Communications (DOI https://doi.org/10.1038/s41467-020-16031-z), showed how the intensity of Cherenkov light coming from patients getting whole breast radiotherapy was affected by the tissue present. The CT scans of each patient were used to calibrate for attenuation of the light for fibroglandular versus adipose tissue variations, as a surrogate for blood based attenuation. The group showed that the calibrated Cherenkov was closer to a true representation of the average dose delivered to the breast, paving the initial step towards quantitative remote dose imaging in vivo.
Rachael Hachadorian, PhD candidate 2021