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  1. Sirun Yang, Dennis Larsen, Maria Pellegrini, Sebastian Meier, Dale F. Mierke, Sophie R. Beeren, Ivan Aprahamian,
    Dynamic enzymatic synthesis of γ-cyclodextrin using a photoremovable hydrazone template, Chem, Volume 7, Issue 8, 2021, Pages 2190-2200, ISSN 2451-9294, https://doi.org/10.1016/j.chempr.2021.05.013.
     
  2. Reinhart EF, Litt NA, Katzenell S, Pellegrini M, Yamamoto A, Ragusa MJ. A highly conserved glutamic acid in ALFY inhibits membrane binding to aid in aggregate clearance. Traffic. 2021 Jan;22(1-2):23-37. doi: 10.1111/tra.12771. Epub 2020 Dec 1. PubMed PMID: 33225481; PubMed Central PMCID: PMC7902475.
  3. Midgett CR, Swindell RA, Pellegrini M, Kull FJ. Publisher Correction: A disulfide constrains the ToxR periplasmic domain structure, altering its interactions with ToxS and bile-salts. Sci Rep. 2020 Jul 16;10(1):12085. doi: 10.1038/s41598-020-69095-8. PubMed PMID: 32669662; PubMed Central PMCID: PMC7363908.
  4. Midgett CR, Swindell RA, Pellegrini M, Jon Kull F. A disulfide constrains the ToxR periplasmic domain structure, altering its interactions with ToxS and bile-salts. Sci Rep. 2020 Jun 2;10(1):9002. doi: 10.1038/s41598-020-66050-5. PubMed PMID: 32488093; PubMed Central PMCID: PMC7265457.
  5. Reinhart EF, Litt NA, Katzenell S, Pellegrini M, Yamamoto A, Ragusa MJ. A highly conserved glutamic acid in ALFY inhibits membrane binding to aid in aggregate clearance. Traffic. 2021 Jan;22(1-2):23-37. doi: 10.1111/tra.12771. Epub 2020 Dec 1. PMID: 33225481; PMCID: PMC7902475.
  6. Barczewski AH, Ragusa MJ, Mierke DF, Pellegrini M. Production, Crystallization, and Structure Determination of the IKK-binding Domain of NEMO. J Vis Exp. 2019 Dec 28;(154):10.3791/60339. doi: 10.3791/60339. PMID: 31929506; PMCID: PMC7359928.
  7. Bauer KM, Dicovitsky R, Pellegrini M, Zhaxybayeva O, Ragusa MJ. The structure of a highly conserved picocyanobacterial protein reveals a Tudor domain with an RNA binding function. J Biol Chem. 2019 Aug 7;. doi: 10.1074/jbc.RA119.007938. [Epub ahead of print] PubMed PMID: 31391250.
  8. Barczewski AH, Ragusa MJ, Mierke DF, Pellegrini M. The IKK-binding domain of NEMO is an irregular coiled coil with a dynamic binding interface. Sci Rep. 2019 Feb 27;9(1):2950. doi: 10.1038/s41598-019-39588-2. PubMed PMID: 30814588; PubMed Central PMCID: PMC6393490.
  9. Zhao Y, Cushing PR, Smithson DC, Pellegrini M, Pletnev AA, Al-Ayyoubi S, Grassetti AV, Gerber SA, Guy RK, Madden DR. Correction: Cysteine modification reveals an allosteric inhibitory site on the CAL PDZ domain. Biosci Rep. 2018 Aug 31;38(4). doi: 10.1042/BSR20180231_COR. Print 2018 Aug 31. PubMed PMID: 29871975; PubMed Central PMCID: PMC6459224.
  10. Zhao Y, Cushing PR, Smithson DC, Pellegrini M, Pletnev AA, Al-Ayyoubi S, Grassetti AV, Gerber SA, Guy RK, Madden DR. Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain. Biosci Rep. 2018 Aug 31;38(4). doi: 10.1042/BSR20180231. Print 2018 Aug 31. PubMed PMID: 29472314; PubMed Central PMCID: PMC6435542.
  11. Xia X, Katzenell S, Reinhart EF, Bauer KM, Pellegrini M, Ragusa MJ. A pseudo-receiver domain in Atg32 is required for mitophagy. Autophagy. 2018;14(9):1620-1628. doi: 10.1080/15548627.2018.1472838. Epub 2018 Aug 1. PubMed PMID: 29909755; PubMed Central PMCID: PMC6135581.
  12. Busatto N, Salvagnin U, Resentini F, Quaresimin S, Navazio L, Marin O, Pellegrini M, Costa F, Mierke DF, Trainotti L. The Peach RGF/GLV Signaling Peptide pCTG134 Is Involved in a Regulatory Circuit That Sustains Auxin and Ethylene Actions. Front Plant Sci. 2017;8:1711. doi: 10.3389/fpls.2017.01711. eCollection 2017. PubMed PMID: 29075273; PubMed Central PMCID: PMC5641559.
  13. Xia X, Pellegrini M, Ragusa MJ. Backbone and side chain resonance assignments for a structured domain within Atg32. Biomol NMR Assign. 2017 Oct;11(2):211-214. doi: 10.1007/s12104-017-9750-y. Epub 2017 Aug 1. PubMed PMID: 28766175; PubMed Central PMCID: PMC5693731.
  14. Privett BR, Pellegrini M, Kovacikova G, Taylor RK, Skorupski K, Mierke D, Kull FJ.Identification of a Small Molecule Activator for AphB, a LysR-Type Virulence Transcriptional Regulator in Vibrio cholerae. Biochemistry. 2017 Jul 25;56(29):3840-3849. doi: 10.1021/acs.biochem.7b00337. Epub 2017 Jul 11. PubMed PMID: 28640592; PubMed Central PMCID: PMC5963692.
  15. Midgett CR, Almagro-Moreno S, Pellegrini M, Taylor RK, Skorupski K, Kull FJ. Bile salts and alkaline pH reciprocally modulate the interaction between the periplasmic domains of Vibrio cholerae ToxR and ToxS. Mol Microbiol. 2017 Jul;105(2):258-272. doi: 10.1111/mmi.13699. Epub 2017 May 17. PubMed PMID: 28464377; PubMed Central PMCID: PMC5498992.
  16. Bucur O, Gaidos G, Yatawara A, Pennarun B, Rupasinghe C, Roux J, Andrei S, Guo B, Panaitiu A, Pellegrini M, Mierke DF, Khosravi-Far R. “A novel caspase 8 selective small molecule potentiates TRAIL-induced cell death.” Sci Rep. 2015 May 11;5:9893. doi: 10.1038/srep09893. PMID: 25962125
  17. Song GJ, Leslie KL, Barrick S, Mamonova T, Fitzpatrick JM, Drombosky KW, Peyser N, Wang B, Pellegrini M, Bauer PM, Friedman PA, Mierke DF, Bisello A. “Phosphorylation of Ezrin-Radixin-Moesin-binding Phosphoprotein 50 (EBP50) by Akt Promotes Stability and Mitogenic Function of S-phase Kinase-associated Protein-2 (Skp2).” J Biol Chem. 2015 290(5):2879-87.  doi: 10.1074/jbc.M114.609768. PMID: 25492869
  18. Yatawara A, Gaidos G, Rupasinghe CN, O’Hara BA, Pellegrini M, Atwood WJ, Mierke DF. “Small-molecule inhibitors of JC polyomavirus infection.” J Pept Sci. 2014 doi: 10.1002/psc.2731. PMID: 25522925
  19. Guo B, Audu CO, Cochran JC, Mierke DF, Pellegrini M. Protein Engineering of the N-terminus of NEMO: structure stabilization and rescue of IKKβ binding. Biochemistry. 2014 53(43):6776-85. PMID: 25286246 DOI:10.1021/bi500861x
  20. Guo B, Gurel PS, Shu R, Higgs HN, Pellegrini M, Mierke DF.Monitoring ATP hydrolysis and ATPase inhibitor screening using (1)H NMR. Chem Commun (Camb). 2014 Sep 6;50(81):12037-9. doi: 10.1039/c4cc04399e. PMID: 25170530
  21.  Fitzpatrick JM, Pellegrini M, Cushing PR, Mierke DF. Small Molecule Inhibition of the Na+/H+ Exchange Regulatory Factor 1 and Parathyroid Hormone 1 Receptor Interaction. Biochemistry. 2014 Sep 15. [Epub ahead of print] PMID: 25171053
  22. Ahn, K. H.; Pellegrini, M.; Tsomaia, N.; Yatawara, A. K.; Kendall, D. A.; Mierke, D. F. Structural Analysis of the Human Cannabinoid Receptor One Carboxyl-Terminus Identifies Two Amphipathic Helices. Biopolymers 2009, 91, 565–573.
  23. Audu, C. O.; Cochran, J. C.; Pellegrini, M.; Mierke, D. F. Recombinant Production of TEV Cleaved Human Parathyroid Hormone. Journal of Peptide Science 2013, 19, 504–510.
  24.  Audu, C. O.; O’Hara, B.; Pellegrini, M.; Wang, L.; Atwood, W. J.; Mierke, D. F. Reining in Polyoma Virus Associated Nephropathy: Design and Characterization of a Template Mimicking BK Viral Coat Protein Cellular Binding. Biochemistry 2012, 51, 8092–8099.
  25.  Audu, C. O.; Plati, J. J.; Pellegrini, M.; Mierke, D. F. Engineering a Soluble Parathyroid Hormone GPCR Mimetic. Proteins: Structure, Function, and Bioinformatics 2013, n/a–n/a.
  26. Baker, D. P.; Lin, E. Y.; Lin, K.; Pellegrini, M.; Petter, R. C.; Chen, L. L.; Arduini, R. M.; Brickelmaier, M.; Wen, D.; Hess, D. M.; Chen, L.; Grant, D.; Whitty, A.; Gill, A.; Lindner, D. J.; Pepinsky, R. B. N-Terminally PEGylated Human Interferon-Β-1a with Improved Pharmacokinetic Properties and in Vivo Efficacy in a Melanoma Angiogenesis Model§. Bioconjugate Chem. 2006, 17, 179–188.
  27. Bisello, A.; Adams, A. E.; Mierke, D. F.; Pellegrini, M.; Rosenblatt, M.; Suva, L. J.; Chorev, M. Parathyroid Hormone-Receptor Interactions Identified Directly by Photocross-Linking and Molecular Modeling Studies. J. Biol. Chem. 1998, 273, 22498–22505.
  28. Chorev, M.; Behar, V.; Yang, Q.; Rosenblatt, M.; Mammi, S.; Maretto, S.; Pellegrini, M.; Peggion, E. Conformation of Parathyroid Hormone Antagonists by CD, Nmr, and Molecular Dynamics Simulations. Biopolymers 1995, 36, 485–495.
  29. Cusack, K. P.; Arnold, L. D.; Barberis, C. E.; Chen, H.; Ericsson, A. M.; Gaza-Bulseco, G. S.; Gordon, T. D.; Grinnell, C. M.; Harsch, A.; Pellegrini, M.; Tarcsa, E. A 13C NMR Approach to Categorizing Potential Limitations of Α,β-Unsaturated Carbonyl Systems in Drug-like Molecules. Bioorganic & Medicinal Chemistry Letters 2004, 14, 5503–5507.
  30. Cushing, P. R.; Vouilleme, L.; Pellegrini, M.; Boisguerin, P.; Madden, D. R. A Stabilizing Influence: CAL PDZ Inhibition Extends the Half-Life of ΔF508-CFTR. Angewandte Chemie International Edition 2010, 49, 9907–9911.
  31.  Fitzpatrick, J.; Pellegrini, M.; Cushing, P.; Mierke, D. Competitive Inhibitors of NHERF1. Abstracts of Papers of the American Chemical Society 2013, 245.
  32. Fitzpatrick, J. M.; Mierke, D.; Pellegrini, M.; Gaidos, G. NMR Screening of Competitive Inhibitors for NHERF 1 and 2. Abstracts of Papers of the American Chemical Society 2010, 240.
  33. Giragossian, C.; Nardi, E.; Savery, C.; Pellegrini, M.; Meini, S.; Maggi, C. A.; Papini, A. M.; Mierke, D. F. Structural Characterization of Lipopeptide Agonists for the Bradykinin B2 Receptor. Biopolymers 2001, 58, 511–520.
  34. Giragossian, C.; Pellegrini, M.; Mierke, D. F. NMR Studies of CCK-8/CCK1 Complex Support Membrane-Associated Pathway for Ligand-Receptor Interaction. Can. J. Physiol. Pharmacol. 2002, 80, 383–387.
  35. Grant, M. A.; Gentile, L. N.; Shi, Q.-L.; Pellegrini, M.; Hawrot, E. Expression and Spectroscopic Analysis of Soluble Nicotinic Acetylcholine Receptor Fragments Derived from the Extracellular Domain of the Α-Subunit†. Biochemistry 1999, 38, 10730–10742.
  36. Lowden, M. J.; Skorupski, K.; Pellegrini, M.; Chiorazzo, M. G.; Taylor, R. K.; Kull, F. J. Structure of Vibrio Cholerae ToxT Reveals a Mechanism for Fatty Acid Regulation of Virulence Genes. PNAS 2010, 107, 2860–2865.
  37. Macdonald, D.; Mierke, D. F.; Li, H.; Pellegrini, M.; Sachais, B.; Krause, J. E.; Leeman, S. E.; Boyd, N. D. Photoaffinity Labeling of Mutant Neurokinin-1 Receptors Reveals Additional Structural Features of the Substance P/NK-1 Receptor Complex†. Biochemistry 2001, 40, 2530–2539.
  38.  Mercurio, E.; Pellegrini, M.; Mierke, D. F. Structure, Dynamics, and Topological Orientation of the Polyether, Ionophore Antibiotic Monensin, in a Micellar Environment. Biopolymers 1997, 42, 759–769.
  39. Mierke, D. F.; Pellegrini, M. Parathyroid Hormone and Parathyroid Hormone-Related Protein: Model Systems for the Development of an Osteoporosis Therapy. Curr. Pharm. Design 1999, 5, 21–36.
  40. Mierke, D. F.; Mao, L.; Pellegrini, M.; Piserchio, A.; Plati, J.; Tsomaia, N. Structural Characterization of the Parathyroid Hormone Receptor Domains Determinant for Ligand Binding. Biochemical Society Transactions 2007, 35, 721.
  41. Mierke, D. F.; Royo, M.; Pellegrini, M.; Sun, H.; Chorev, M. Peptide Mimetic of the Third Cytoplasmic Loop of the PTH/PTHrP Receptor. J. Am. Chem. Soc. 1996, 118, 8998–9004.
  42.  Morgan, B.; Anderson, W.; Coy, D.; Culler, M.; MacArthur, M.; Mierke, D.; Pellegrini, M.; Piserchio, A.; Allee, D. S.; Taylor, J. Identification and Exploitation of Structural Foci That Influence Conformational Mobility in Somatostatin Agonists and Antagonists. In Peptides for the New Millennium; Fields, G. B.; Tam, J. P.; Barany, G., Eds.; American Peptide Symposia; Springer Netherlands, 2002; pp. 245–247.
  43. Pellegrini, M.; Bisello, A.; Rosenblatt, M.; Chorev, M.; Mierke, D. F. Conformational Studies of RS-66271, an Analog of Parathyroid Hormone-Related Protein with Pronounced Bone Anabolic Activity†. J. Med. Chem. 1997, 40, 3025–3031.
  44. Pellegrini, M.; Bisello, A.; Rosenblatt, M.; Chorev, M.; Mierke, D. F. Binding Domain of Human Parathyroid Hormone Receptor:  From Conformation to Function†,‡. Biochemistry 1998, 37, 12737–12743.
  45. Pellegrini, M.; Bremer, A. A.; Ulfers, A. L.; Boyd, N. D.; Mierke, D. F. Molecular Characterization of the Substance P·Neurokinin-1 Receptor Complex Development of an Experimentally Based Model. J. Biol. Chem. 2001, 276, 22862–22867.
  46. Pellegrini, M.; Gobbo, M.; Rocchi, R.; Peggion, E.; Mammi, S.; Mierke, D. F. Threonine6-Bradykinin: Conformational Study of a Flexible Peptide in Dimethyl Sulfoxide by NMR and Ensemble Calculations. Peptide Science 1996, 40, 561–569.
  47. Pellegrini, M.; Krushinskie, D.; Cuervo, H.; Sun, Y.; Day, E. S.; Schneider, P.; Zheng, T. S. Fn14: A Common Structural Framework for Species Sequence Divergence. In Advances in Tnf Family Research; Wallach, D.; Kovalenko, A.; Feldman, M., Eds.; 2011; Vol. 691, pp. 689–690.
  48. Pellegrini, M.; Liehr, S.; Fisher, A. L.; Laub, P. B.; Cooperman, B. S.; Mierke, D. F. Structure-Based Optimization of Peptide Inhibitors of Mammalian Ribonucleotide Reductase†,‡. Biochemistry 2000, 39, 12210–12215.
  49. Pellegrini, M.; Mammi, S.; Gobbo, M.; Rocchi, R.; Peggion, E. Conformation of Cyclobradykinin by Nmr and Distance Geometry Calculations. Biopolymers 1995, 36, 461–472.
  50. Pellegrini, M.; Mammi, S.; Peggion, E.; Mierke, D. F. Threonine6-Bradykinin:  Structural Characterization in the Presence of Micelles by Nuclear Magnetic Resonance and Distance Geometry†. J. Med. Chem. 1997, 40, 92–98.
  51. Pellegrini, M.; Mierke, D. F. Threonine6-Bradykinin:  Molecular Dynamics Simulations in a Biphasic Membrane Mimetic†. J. Med. Chem. 1997, 40, 99–104.
  52. Pellegrini, M.; Mierke, D. F. Molecular Complex of Cholecystokinin-8 and N-Terminus of the Cholecystokinin A Receptor by NMR Spectroscopy‡. Biochemistry 1999, 38, 14775–14783.
  53. Pellegrini, M.; Mierke, D. F. Structural Characterization of Peptide Hormone/receptor Interactions by NMR Spectroscopy. Peptide Science 1999, 51, 208–220.
  54. Pellegrini, M.; Royo, M.; Chorev, M.; Mierke, D. F. Conformational Characterization of a Peptide Mimetic of the Third Cytoplasmic Loop of the G-Protein Coupled Parathyroid Hormone/parathyroid Hormone Related Protein Receptor. Peptide Science 1996, 40, 653–666.
  55. Pellegrini, M.; Royo, M.; Chorev, M.; Mierke, D. F. Conformational Consequences of I, I + 3 Cystine Linkages: Nucleation for Α-Helicity? The Journal of Peptide Research 1997, 49, 404–414.
  56.  Pellegrini, M.; Royo, M.; Rosenblatt, M.; Chorev, M.; Mierke, D. F. Addressing the Tertiary Structure of Human Parathyroid Hormone-(1–34). J. Biol. Chem. 1998, 273, 10420–10427.
  57.  Pellegrini, M.; Tancredi, M.; Rovero, P.; Mierke, D. F. Probing the Topological Arrangement of the N- and C-Terminal Residues of Bradykinin for Agonist Activity at the B1 Receptor†. J. Med. Chem. 1999, 42, 3369–3377.
  58.  Pellegrini, M.; Weitz, I.; Chorev, M.; Mierke, D. F. Conformational Investigation of a Novel, Dipeptide Based Molecular Scaffold. Letters in Peptide Science 1998, 5, 151–153.
  59. Pellegrini, M.; Weitz, I. S.; Chorev, M.; Mierke, D. F. A Trisubstituted 1,4-Diazepine-3-One-Based Dipeptidomimetic:  Conformational Characterization by NMR and Computer Simulation. J. Am. Chem. Soc. 1997, 119, 2430–2436.
  60. Pellegrini, M.; Willen, L.; Perroud, M.; Krushinskie, D.; Strauch, K.; Cuervo, H.; Day, E. S.; Schneider, P.; Zheng, T. S. Structure of the Extracellular Domains of Human and Xenopus Fn14: Implications in the Evolution of TWEAK and Fn14 Interactions. FEBS Journal 2013, 280, 1818–1829.
  61. Piserchio, A.; Pellegrini, M.; Mehta, S.; Blackman, S. M.; Garcia, E. P.; Marshall, J.; Mierke, D. F. The PDZ1 Domain of SAP90 Characterization of Structure and Binding. J. Biol. Chem. 2002, 277, 6967–6973.
  62. Prado, G. N.; Mierke, D. F.; Pellegrini, M.; Taylor, L.; Polgar, P. Motif Mutation of Bradykinin B2 Receptor Second Intracellular Loop and Proximal C Terminus Is Critical for Signal Transduction, Internalization, and Resensitization. J. Biol. Chem. 1998, 273, 33548–33555.
  63. Rölz, C.; Pellegrini, M.; Mierke, D. F. Molecular Characterization of the Receptor−Ligand Complex for Parathyroid Hormone†. Biochemistry 1999, 38, 6397–6405.
  64.  Rovero, P.; Pellegrini, M.; Di Fenza, A.; Meini, S.; Quartara, L.; Maggi, C. A.; Formaggio, F.; Toniolo, C.; Mierke, D. F. Agonist Activity at the Kinin B1 Receptor:  Structural Requirements of the Central Tetrapeptide. J. Med. Chem. 2001, 44, 274–278.
  65.  Rushe, M.; Silvian, L.; Bixler, S.; Chen, L. L.; Cheung, A.; Bowes, S.; Cuervo, H.; Berkowitz, S.; Zheng, T.; Guckian, K.; Pellegrini, M.; Lugovskoy, A. Structure of a NEMO/IKK-Associating Domain Reveals Architecture of the Interaction Site. Structure 2008, 16, 798–808.
  66.  Seck, T.; Pellegrini, M.; Florea, A. M.; Grignoux, V.; Baron, R.; Mierke, D. F.; Horne, W. C. The Δe13 Isoform of the Calcitonin Receptor Forms a Six-Transmembrane Domain Receptor with Dominant-Negative Effects on Receptor Surface Expression and Signaling. Molecular Endocrinology 2005, 19, 2132–2144.
  67. Tsomaia, N.; Pellegrini, M.; Hyde, K.; Gardella, T. J.; Mierke, D. F. Toward Parathyroid Hormone Minimization:  Conformational Studies of Cyclic PTH(1−14) Analogues. Biochemistry 2004, 43, 690–699.
  68.  Weitz, I. S.; Pellegrini, M.; Mierke, D. F.; Chorev, M. Synthesis of a Trisubstituted 1,4-Diazepin-3-One-Based Dipeptidomimetic as a Novel Molecular Scaffold. J. Org. Chem. 1997, 62, 2527–2534.
  69. Weitz, I. S.; Pellegrini, M.; Royo, M.; Mierke, D. F.; Chorev, M. 1,2,5-Trisubstituted 1,4-Diazepine-3-One: A Novel Dipeptidomimetic Molecular Scaffold. Letters in Peptide Science 1998, 5, 83–86.

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