Britton Goodale, Ph.D., former Project 3 Research Assistant and former Project 3 PostDoc Trainee, will be presenting at the SOT (Society of Toxicology) meeting in March on “Single Cell RNA-Seq Reveals Long-Term, Cell Type-Specific Effects of Early-Life Arsenic Exposure on Immune Gene Expression,” as part of the Symposium session “Applications of Single Cell Profiling Methods to Enhance Mechanistic Understanding of Toxicological Responses.” Her talk will present data from the research she and Kevin Hsu, Ph.D, former Project 3 PostDoc Trainee, did together for SRP Project 3 (Stanton and Enelow labs).

The following papers have recently been published by our SRP faculty:

1) Margaret Karagas, Ph.D., Project 4 Leader, is co-author of: Peacock JL, Palys TJ, Halchenko Y, Sayarath V, Takigawa CA, Murphy SE, Peterson LA, Baker ER, Karagas MR. Assessing tobacco smoke exposure in pregnancy from self-report, urinary cotinine and NNAL: a validation study using the New Hampshire Birth Cohort Study. BMJ Open. 2022 Feb 7;12(2):e054535. doi: 10.1136/bmjopen-2021-054535. PubMed PMID: 35131829.

2) Margaret Karagas, Ph.D., Project 4 Leader, is co-author of: Taylor VF, Karagas MR. 2022. Exposure to arsenolipids and inorganic arsenic from marine-sourced dietary supplements. Chemosphere. 2022. Feb 16;296:133930. doi: 10.1016/j.chemosphere.2022.133930. [Epub ahead of print] PubMed PMID: 35182530.

3) Margaret Karagas, Ph.D., Project 4 Leader and Brian Jackson, Ph.D., TEAC co-Leader, are co-authors of: Howe CG, Nozadi SS, Garcia E, O’Connor TG, Starling AP, Farzan SF, Jackson BP, Madan JC, Alshawabkeh AN, Cordero JF, Bastain TM, Meeker JD, Breton CV, Karagas MR. Prenatal metal(loid) mixtures and birth weight for gestational age: A pooled analysis of three cohorts participating in the ECHO program. 2022. Environ Int. 2022 Jan 23;161:107102. doi: 10.1016/j.envint.2022.107102. [Epub ahead of print] PubMed PMID: 35081493.

4) Brian Jackson, Ph.D. and Tracy Punshon, Ph.D., co-Leaders of TEAC, are co-authors of, Punshon T, Jackson BP, Donohue A, Hong C, Rothenberg SE. Distribution and accumulation of mercury in pot-grown African rice cultivars (Oryza glaberrima Steud. and Oryza sativa L.) determined via LA-ICP-MS.Environ Geochem Health 2022 Jan 4. doi: 10.1007/s10653-021-01169-6. Online ahead of print. PMID: 34981270.

5) Brian Jackson, Ph.D., TEAC co-Leader, is co-author of: Cassidy R. VanderSchee, David Frier,David Kuter, Koren K. Mann, Brian P. Jackson, D. Scott Bohle  Quantification of local zinc and tungsten deposits in bone with LA-ICP-MS using novel hydroxyapatite-collagen calibration standards”. Journal of analytical atomic spectrometry. NIHMSID: NIHMS1746661.

Celia Chen, Ph.D. Dartmouth SRP Director and Project 2 Leader, is featured in NIEHS’ (National Instituted of Environmental Sciences) March 2022 PEPH (Partnership for Environmental Health) newsletter. The newsletter story highlights her research on “…how pollutants accumulate in freshwater and marine food webs where they can pose a threat to human health” and PFAS. The story also features our SRP work.

The following papers have recently been published by our SRP faculty and current and former Trainees. These include:

1) Margaret Karagas, Ph.D., Project 4 Leader, is co-author of: Leeming RC, Karagas MR, Zens MS, Schned AR, Seigne JD, Passarelli MN. Bladder Cancer Risk Variants and Overall and Disease-Specific Survival in Two Independent Cohorts. BJU Int. 2021 Nov 14;. doi: 10.1111/bju.15640. [Epub ahead of print] PubMed PMID: 34775665.

2) Margaret Karagas, Ph.D., Project 4 Leader and Hannah Laue, ScD., Project 4 Trainee and PostDoc, are co-authors of: Laue HE, Karagas MR, Coker MO, Bellinger DC, Baker ER, Korrick SA, Madan JC. Sex-specific relationships of the infant microbiome and early-childhood behavioral outcomes. Pediatr Res. 2021 Nov 4;. doi: 10.1038/s41390-021-01785-z. [Epub ahead of print] PubMed PMID: 347328161. Additional information.

3) Margaret Karagas, Ph.D., Project 4 Leader and Brett Doherty, former Project 4 Trainee and PostDoc, are co-authors of: Doherty BT, McRitchie SL, Pathmasiri WW, Stewart DA, Kirchner D, Anderson KA, Gui J, Madan JC, Hoen AG, Sumner SJ, Karagas MR, Romano ME. Chemical exposures assessed via silicone wristbands and endogenous plasma metabolomics during pregnancy. J Expo Sci Environ Epidemiol. 2021 Oct 26;. doi: 10.1038/s41370-021-00394-6. [Epub ahead of print] PubMed PMID: 34702988.

Complete Website List of our SRP papers.

SRP Trainee and Postdoctoral Researcher Pianpian Wu, Ph.D., and SRP Director Celia Chen, Ph.D., are co-authors of the paper “Elevated temperature and browning increase dietary methylmercury, but decrease essential fatty acids at the base of lake food webs.” The study, which was published in Scientific Reports, focuses on the potential effects of climate change on water and the food web. According to Dr. Chen, “Understanding how mercury and fatty acids in aquatic food webs respond to climate change will tell us about the embedded risks at the top of the food web.” More information.

SRP Project 4 Trainee and Postdoctoral Researcher Hannah Laue, Ph.D., recently presented at two scientific conferences. At the 2021 virtual Northeast Regional IDeA Conference in August, Hannah gave a talk on “Bacterial modification of the association between arsenic and autism-related social behavior scores.” Her presentation was selected as a 3^rd place winning talk. At the 33^rd Annual Scientific Conference of the International Society for Environmental Epidemiology (E-Poster Discussion Session 13) virtual meeting in August, Dr. Laue presented a poster on the “Bacterial modification of the association between arsenic and autism-related social behavior scores.”

Dartmouth SRP’s Dragonfly Mercury Project (DMP) recently received funding to continue and expand the project. The Dartmouth DMP utilizes dragonfly larvae to engage students in research, increase scientific and data literacy, and inform about regionally relevant mercury and environmental risks. The DMP is a collaboration with Upper Valley schools in NH and VT communities including Claremont  and Orford NH and Woodstock and Hartford VT. This project provides equal opportunity for experiential education, utilizing mercury science as a tool. The project is being done in collaboration with Dr. Sarah Nelson of the Appalachian Mountain Club. Continue reading Dragonfly Mercury Project Receives Multiple Grants →

Kevin Hsu, recent former SRP Project 3 Trainee, was awarded his Ph.D. in August 2021. His thesis title is “Impact of arsenic exposure on antiviral immune responses to Influenza A.” He currently is a Research PostDoctoral Fellow in Pulmonary Research in the Enelow lab at Dartmouth-Hitchcock Medical Center (DHMC) in Lebanon, NH. He is doing research on Cystic Fibrosis.

Several papers have been published recently by our SRP faculty and others connected to our SRP. These include:

1) David Salt, Ph.D., former Project 1 co-Leader, is co-author of: Busoms S, Terés J, Yant L, Poschenrieder C, Salt DE. Adaptation to coastal soils through pleiotropic boosting of ion and stress hormone concentrations in wild Arabidopsis thaliana. New Phytol. 2021 Oct;232(1):208-220. doi: 10.1111/nph.17569. Epub 2021 Jul 19. PubMed PMID: 34153129; PubMed Central PMCID: PMC8429122.

2) Margaret Karagas, Ph.D., Project 4 Leader and Antonio Signes-Pastor, Ph.D., former Project 4 Trainee, are co-authors of: Signes-Pastor AJ, Martinez-Camblor P, Baker E, Madan J, Guill MF, Karagas MR. Prenatal exposure to arsenic and lung function in children from the New Hampshire Birth Cohort Study. Environ Int. 2021 Oct;155:106673. doi: 10.1016/j.envint.2021.106673. Epub 2021 Jun 3. PubMed PMID: 34091160; PubMed Central PMCID: PMC8353991.

3) Margaret Karagas, Ph.D., Project 4 Leader is co-author of: Sauder KA, Harte RN, Ringham BM, Guenther PM, Bailey RL, Alshawabkeh A, Cordero JF, Dunlop AL, Ferranti EP, Elliott AJ, Mitchell DC, Hedderson MM, Avalos LA, Zhu Y, Breton CV, Chatzi L, Ran J, Hertz-Picciotto I, Karagas MR, Sayarath V, Hoover J, MacKenzie D, Lyall K, Schmidt RJ, O’Connor TG, Barrett ES, Switkowski KM, Comstock SS, Kerver JM, Trasande L, Tylavsky FA, Wright RJ, Kannan S, Mueller NT, Catellier DJ, Glueck DH, Dabelea D. Disparities in Risks of Inadequate and Excessive Intake of Micronutrients during Pregnancy. J Nutr. 2021 Sep 7;. doi: 10.1093/jn/nxab273. [Epub ahead of print] PubMed PMID: 34494118.

4) Mary Lou Guerinot, Ph.D., Project 1 Leader, and Tracy Punshon, Ph.D., Trace Element Analysis co-Leader, are co-authors of:  Lee S, Lee J, Ricachenevsky FK, Punshon T, Tappero R, Salt DE, Guerinot ML. Redundant roles of four ZIP family members in zinc homeostasis and seed development in Arabidopsis thaliana. Plant J. 2021 Sep 24;. doi: 10.1111/tpj.15506. [Epub ahead of print] PubMed PMID: 34559918.

5) Kate Buckman, Ph.D., Research Scientist with Project 2 and Research Translation–Community Engagement Core Liasion, is co-author of: Farrell A, Buckman K, Hall SR, Muñoz I, Bieluch K, Zoellick B, Disney J. Adaptations to a Secondary School-Based Citizen Science Project to Engage Students in Monitoring Well Water for Arsenic during the COVID-19 Pandemic. J STEM Outreach. 2021 Jul;4(2). doi: 10.15695/jstem/v4i2.05. Epub 2021 Jul 19. PubMed PMID: 34532651; PubMed Central PMCID: PMC8442737.

Complete Website List of our SRP papers.

Brian Jackson, PH.D., Trace Element Anaylsis Core (TEAC) co -leader, gave a talk on the TEAC at the August regional NH INBRE annual meeting. INBRE is a “network of shared resources and information for NH faculty and students involved in original scientific research.”