News

Photos: Lars BlackmoreText: Tammara Wood and Karin Curtis-Hill Attendees between presentations On April 3rd, 2024 members of the Center for Quantitative Biology (CQB) gathered at the Hanover Inn to share their updates, accomplishments, and plans, with the CQB community, meet with their External Advisory Committee (EAC), and enjoy some good company and good food! EAC Members: Dr. Kelley Thomas, University of New Hampshire Dr. Cathy Wu, University of Delaware Dr. Paul Robson, Jackson Laboratory  Introduction and Updates   Director, …

For anyone who wants to trial the soon-to-be-released 5K gene panels for Xenium, 10x has announced a grant program to fund an exciting project. The Single Cell Genomics Core and Genomics Shared Resource will support sample preparation, instrument run and data delivery should you receive the award. Learn more and apply for the Grant Submission deadline: June 18, 2024 What would you do with more: more transcripts, more genes, more exploration, more single cell spatial …

A lot has been happening at the CQB and we are excited to share some of the most important news with you in our CQB Newsletter!  

10x Genomics and the Center for Quantitative Biology teamed up for a grant program to support an innovative research project at Dartmouth. The winner received a Visium CytAssist slide, library prep and sequencing at no cost.

Optimization of data analysis ecosystems is an important frontier in data analytics science. Access to compute resources with sufficient RAM and technology to analyze genomic datasets is often a rate limiting step to deploying analysis workflows. Furthermore, as datasets become larger and more complex file sizes increase exponentially and storage costs increase in concert with the size of the data. The increased availability of compute resources and the multiple storage tiers available on the cloud …

On April 6th, 2023 the Center for Quantitative Biology held its annual meeting at the Hanover Inn in Hanover NH. The meeting is part of an annual review of the COBRE grant by the External Advisory Committee, but also an opportunity for members of the center and the larger community to get together, share their work, and make new acquaintances over breakfast or a glass of wine.

Members of the audience listen to a speaker at the Single Cell and Spatial Genomics Symposium. Drawing by Karin Curtis-Hill. In November, attendees of the Single Cell and Spatial Genomics Symposium began arriving at Auditorium G, DHMC, around 8:30am to grab some breakfast and caffeine before settling into their seats to learn about Single Cell Genomics and Spatial Genomics technologies.  Fred Kolling The symposium kicked off with a welcome by Fred Kolling, Director Single Cell …

CQB Director, Mike Whitfield, recently announced changes to the leadership of the Data Analytics Core appointing Shannon Soucy and Owen Wilson have been appointed as Co-Directors of the CQB Data Analytics Core.

Project PI H. Robert Frost graduated from the CQB COBRE in September of 2022 after receiving an R35 MIRA award (R35GM146586, Gene set analysis of single cell genomics). Dr. Frost credits the CQB with providing the critical funding, mentorship and core services needed to advance his independent research and support collaborative projects with other Dartmouth faculty.  During his three years with the CQB, his group developed a number of computational methods for the analysis of …

Dr. Benjamin Ross joins the CQB as a Pilot Investigator We are happy to welcome Dr. Benjamin Ross to the CQB as one of our pilot investigators. His pilot project "Revealing the impact of tryptophan metabolism on host-microbe and microbe-microbe interactions in the gut" will help reveal how metabolism of tryptophan impacts microbe-microbe and host-microbe interactions. Dr. Sladjana Skopelja-Gardner becomes a full Investigator with the CQB Congratulations to Dr. Sladjana Skopelja-Gardner who became a full …

Author: Tammara Wood Photography: Lars Blackmore, www.ameridane.org CQB Director Mike Whitfield gives a program overview The Center for Quantitative Biology and members of its External Advisory Committee (EAC) gathered Wednesday, April 6th at the Hanover Inn to review the progress of the CQB COBRE grant and share research updates. Attendees included CQB investigators, mentors, leadership, and staff, as well as members of the EAC. CQB Director, Dr. Mike Whitfield, opened the event with a …

The NIH has awarded a grant to a team of researchers and clinicians at Dartmouth’s Geisel School of Medicine and Dartmouth-Hitchcock Medical Center (DHMC) to track the development and spread of COVID-19 variants that are detected in the Upper Valley. The one-year project is part of an initiative by the NIH’s National Institute of General Medical Sciences (NIGMS) to support surveillance studies of SARS-CoV-2 viral strains in rural, underserved communities. Read the full article: https://geiselmed.dartmouth.edu/news/2021/geisel-and-dartmouth-hitchcock-receive-grant-to-monitor-covid-19-variants-in-the-region/

Dear Colleagues, The Center for Quantitative Biology is pleased to announce contributions to Munck-Pfefferkorn applications. In an effort to support innovative applications of single cell genomics and spatial transcriptomics technologies, the Single Cell Genomics (SCG) core will provide additional funding for Munck-Pfefferkorn applications leveraging these tools. Up to $10k in funding is available to match budget line items relating directly to single cell genomics or spatial transcriptomics experiments conducted in the SCG core. Interested applicants should send …

The Center for Quantitative Biology’s Single Cell Genomics Core has recently enabled Spatial Transcriptomics capabilities by implementing the 10x Genomics Visium workflow. As part of our effort to gain experience with new tissue/sample types and to promote the method across campus, we are offering 1:1 matching funds for a limited number of 10x Visium experiments. Each project will include a tissue optimization step specific to the chosen sample, and a full Gene Expression Slide capable of interrogating 4 tissue sections, 6.6mm^2 or less …

The Single Cell Genomics Core has added several exciting new services to its catalogue: Spatial Transcriptomics Using the 10x Genomics Visium technology, we can now measure gene expression in the context of tissue specimens. This is a discovery-mode application and requires no a priori knowledge of genes of interest, providing a powerful complement to single cell RNA-seq technologies. Sample Multiplexing We leverage barcoded antibody reagents (TotalSeq, BioLegend) as well as lipidated oligos (available in the …

By Tim Dean, Dartmouth Medicine, Spring ’20 Single-cell genomics is a rapidly evolving field; having a dedicated center with resources behind it gives us the ability to bring on new technologies, test them, and figure out which ones are best for our needs. Read the full article here

John Robertson, Ph.D., is returning to campus to present two seminars on writing winning proposals. The NIH seminar will be December 12th 8:30 AM to 4:30 PM and the NSF seminar will be December 13th 8:30 AM to 12:00 PM. Both seminars will be in the Dartmouth Class of 1978 Life Sciences Center. These free opportunities are sponsored by GrantGPS. For more information and to register, click here.

Every other Monday meetings will resume September 9, 2019. Please visit the calendar under Upcoming Events for more information. You can access the SCIG's schedule here.